Biology:Geranylfarnesyl diphosphate synthase
From HandWiki
Short description: Enzyme
| Geranylfarnesyl diphosphate synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.5.1.81 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Geranylfarnesyl diphosphate synthase (EC 2.5.1.81, FGPP synthase, (all-E) geranylfarnesyl diphosphate synthase, GFPS, Fgs) is an enzyme with systematic name geranylgeranyl-diphosphate:isopentenyl-diphosphate transtransferase (adding 1 isopentenyl unit).[1][2][3][4] This enzyme catalyses the following chemical reaction
- geranylgeranyl diphosphate + isopentenyl diphosphate [math]\displaystyle{ \rightleftharpoons }[/math] (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate
The enzyme from Methanosarcina mazei is involved in biosynthesis of the polyprenyl side-chain of methanophenazine.
References
- ↑ "Geranylfarnesyl diphosphate synthase from Methanosarcina mazei: Different role, different evolution". Biochemical and Biophysical Research Communications 393 (1): 16–20. February 2010. doi:10.1016/j.bbrc.2010.01.063. PMID 20097171.
- ↑ "Novel prenyltransferase gene encoding farnesylgeranyl diphosphate synthase from a hyperthermophilic archaeon, Aeropyrum pernix. Molecularevolution with alteration in product specificity". European Journal of Biochemistry 267 (2): 321–8. January 2000. doi:10.1046/j.1432-1327.2000.00967.x. PMID 10632701.
- ↑ "A novel prenyltransferase, farnesylgeranyl diphosphate synthase, from the haloalkaliphilic archaeon, Natronobacterium pharaonis". FEBS Letters 341 (2-3): 291–4. March 1994. doi:10.1016/0014-5793(94)80475-3. PMID 8137956.
- ↑ "Alteration of product specificity of Aeropyrum pernix farnesylgeranyl diphosphate synthase (Fgs) by directed evolution". Protein Engineering, Design & Selection 17 (11): 771–7. November 2004. doi:10.1093/protein/gzh089. PMID 15548566.
External links
- Geranylfarnesyl+diphosphate+synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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