Biology:Geranylgeranylglycerol-phosphate geranylgeranyltransferase
| geranylgeranylglycerol-phosphate geranylgeranyltransferase | |||||||||
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| Identifiers | |||||||||
| EC number | 2.5.1.42 | ||||||||
| CAS number | 124650-68-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a geranylgeranylglycerol-phosphate geranylgeranyltransferase (EC 2.5.1.42) is an enzyme that catalyzes the chemical reaction
- geranylgeranyl diphosphate + sn-3-O-(geranylgeranyl)glycerol 1-phosphate [math]\displaystyle{ \rightleftharpoons }[/math] diphosphate + 2,3-bis-O-(geranylgeranyl)glycerol 1-phosphate
Thus, the two substrates of this enzyme are geranylgeranyl diphosphate and sn-3-O-(geranylgeranyl)glycerol 1-phosphate, whereas its two products are diphosphate and 2,3-bis-O-(geranylgeranyl)glycerol 1-phosphate.
This enzyme belongs to the family of transferases, specifically those transferring aryl groups or alkyl groups other than methyl groups. The systematic name of this enzyme class is geranylgeranyl diphosphate:sn-3-O-(geranylgeranyl)glycerol 1-phosphate geranylgeranyltransferase. Other names in common use include geranylgeranyloxyglycerol phosphate geranylgeranyltransferase, and geranylgeranyltransferase II.
Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2F6U and 2F6X.
References
- "Biosynthesis of archaebacterial membranes. Formation of isoprene ethers by a prenyl transfer reaction". J. Am. Chem. Soc. 112 (3): 1264–1265. 1990. doi:10.1021/ja00159a067.
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