Biology:HAAO
3-hydroxyanthranilate 3,4-dioxygenase (EC 1.13.11.6) is an enzyme encoded by the HAAO gene that catalyzes the chemical reaction
The two substrates of this enzyme are 3-hydroxyanthranilic acid and oxygen. Its product is 2-amino-3-carboxymuconic semialdehyde.[1][2][3][4]
This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O2 as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2.
The systematic name of this enzyme class is 3-hydroxyanthranilate:oxygen 3,4-oxidoreductase (decyclizing). Other names in common use include 3-hydroxyanthranilate oxygenase, 3-hydroxyanthranilic acid oxygenase, 3-hydroxyanthranilic oxygenase, 3-hydroxyanthranilic acid oxidase and 3HAO. This enzyme participates in tryptophan metabolism. It employs one cofactor, iron.
Structural studies
As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1YFU, 1YFW, 1YFX, 1YFY, 1ZVF, and 2QNK.h
References
- ↑ Enzyme 1.13.11.6 at KEGG Pathway Database.
- ↑ "Purification and Properties of 3-Hydroxyanthranilic Acid Oxidase". Journal of Biological Chemistry 236 (11): 3076–3082. 1961. doi:10.1016/S0021-9258(19)76432-1.
- ↑ The Enzymes. 8 (2nd ed.). New York: Academic Press. 1963. pp. 353-371.
- ↑ "Reassignment of the human aldehyde dehydrogenase ALDH8A1 (ALDH12) to the kynurenine pathway in tryptophan catabolism". The Journal of Biological Chemistry 293 (25): 9594–9603. June 2018. doi:10.1074/jbc.RA118.003320. PMID 29703752.
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