Biology:Heat shock protein 47

From HandWiki
Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Heat shock protein 47, also known as SERPINH1 is a serpin which serves as a human chaperone protein for collagen.[1][2]

Function

This protein is a member of the serpin superfamily of serine proteinase inhibitors. Its expression is induced by heat shock. HSP47 is expressed in the endoplasmic reticulum. These cells synthesize and secrete type I and type II collagen. [3] The protein localizes to the endoplasmic reticulum lumen and binds collagen; thus it is thought to be a molecular chaperone involved in the maturation of collagen molecules. HSP47 is essential for the correct folding of procollagen. to this protein have been found in patients with rheumatoid arthritis.[1]

Structure

HSP47 contains 3 beta sheets and 9 alpha helices. After binding with collagen no conformation change is observed.[4]

Interactions

Heat shock protein 47 has been shown to interact with collagens I, II, III, IV and V.[5] It is involved in the secretion of collagen as well as the processing, assembly, and folding of collagen proteins. Hsp 47 binds specifically to procollagen and collagen only. The protein recognizes the triple helix of procollagen, two HSP47 proteins will bind to the leading and trailing strands of procollagen.[4]

Research on role in preventing deep vein thrombosis

Research published in 2023 indicates a potential role of HSP47 regarding deep vein thrombosis.[6] [7] This initial research will be followed by additional studies.

Role in Fibrosis

Fibrosis is the scarring of connective tissue, one attribute is the excess deposition of collagen in the extracellular matrix of tissue. Research has shown that HSPs have a role in fibrotic diseases.[8] HSP47 has been shown to be pro-fibrosis in various fibrotic diseases. During the process of fibrosis, HSP47 is expressed and is involved in the production of collagen.[9] HSP47 could be a potential therapeutic agent for fibrotic disease, a down-regulation of HSP47 leads to decreased fibrotic progression.[10]

References

  1. ↑ 1.0 1.1 "Entrez Gene: SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=871. 
  2. ↑ "The molecular interactions of heat shock protein 47 (Hsp47) and their implications for collagen biosynthesis". The Journal of Biological Chemistry 276 (52): 49310–9. December 2001. doi:10.1074/jbc.M108896200. PMID 11592970. 
  3. ↑ Williams, R. Sanders (21 March 2000). "Heat Shock Protein 47: A Chaperone for the Fibrous Cap?" (in en). Circulation 101 (11): 1227–1228. doi:10.1161/01.CIR.101.11.1227. PMID 10725278. http://circ.ahajournals.org/content/101/11/1227.full. Retrieved 11 December 2017. 
  4. ↑ 4.0 4.1 Widmer, C.; Gebauer, J.M.; Baumann, U. (2013-01-09). "Molecular basis for the action of the collagen-specific chaperone Hsp47 SERPINH1 and its structure-specific client recognition.". Proceedings of the National Academy of Sciences of the United States of America 109 (33): 13243–13247. doi:10.2210/pdb3zha/pdb. PMID 22847422. PMC 3421173. http://dx.doi.org/10.2210/pdb3zha/pdb. Retrieved 2023-11-26. 
  5. ↑ "Interactions of heat shock protein 47 with collagen and the stress response: an unconventional chaperone model?". Life Sciences 87 (19–22): 579–86. November 2010. doi:10.1016/j.lfs.2010.09.024. PMID 20888348. 
  6. ↑ Schattner, Mirta, Sleep like a bear, Science, April 13, 2023
  7. ↑ Garcia de Jesús, Erin, Hibernating bears don’t get blood clots. Now scientists know why, Science News, April 13, 2023
  8. ↑ Balasubramaniam, Boopathi; Balamurugan, Krishnaswamy (2020), "Role of Heat Shock Factors in Diseases and Immunity", Heat Shock Proteins in Human Diseases (Cham: Springer International Publishing): pp. 197–210, doi:10.1007/7515_2020_21, ISBN 978-3-030-62288-6, http://dx.doi.org/10.1007/7515_2020_21, retrieved 2023-11-26 
  9. ↑ Kim, Hae-Ji; Park, Joo-Hoo; Shin, Jae-Min; Yang, Hyun-Woo; Lee, Heung-Man; Park, Il-Ho (2020-06-09). "Author Correction: TGF-β1-induced HSP47 regulates extracellular matrix accumulation via Smad2/3 signaling pathways in nasal fibroblasts". Scientific Reports 10 (1): 9585. doi:10.1038/s41598-020-66547-z. ISSN 2045-2322. PMID 32514115. 
  10. ↑ Sakamoto, Noriho; Okuno, Daisuke; Tokito, Takatomo; Yura, Hirokazu; Kido, Takashi; Ishimoto, Hiroshi; Tanaka, Yoshimasa; Mukae, Hiroshi (2023-08-25). "HSP47: A Therapeutic Target in Pulmonary Fibrosis". Biomedicines 11 (9): 2387. doi:10.3390/biomedicines11092387. ISSN 2227-9059. PMID 37760828. 

Further reading

  • "The possible role of colligin/HSP47, a collagen-binding protein, in the pathogenesis of human and experimental fibrotic diseases". Histology and Histopathology 14 (4): 1199–212. October 1999. PMID 10506936. 
  • "Serpin structure, mechanism, and function". Chemical Reviews 102 (12): 4751–804. December 2002. doi:10.1021/cr010170. PMID 12475206. 
  • "Cloning of a human collagen-binding protein, and its homology with rat gp46, chick hsp47 and mouse J6 proteins". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1129 (2): 246–8. January 1992. doi:10.1016/0167-4781(92)90498-o. PMID 1309665. 
  • "Isolation, characterization and chromosomal assignment of human colligin-2 gene (CBP2)". Cytogenetics and Cell Genetics 71 (2): 182–6. 1995. doi:10.1159/000134103. PMID 7656593. 
  • "Structure of the gene encoding human colligin-2 (CBP2)". Gene 194 (2): 301–3. July 1997. doi:10.1016/S0378-1119(97)00209-6. PMID 9272875. 
  • "Detailed map of a region commonly amplified at 11q13-->q14 in human breast carcinoma". Cytogenetics and Cell Genetics 79 (1–2): 125–31. 1998. doi:10.1159/000134699. PMID 9533029. 
  • "Isolation and characterization of a rheumatoid arthritis-specific antigen (RA-A47) from a human chondrocytic cell line (HCS-2/8)". Biochemical and Biophysical Research Communications 245 (3): 679–83. April 1998. doi:10.1006/bbrc.1998.8505. PMID 9588174. 
  • "The human genome has only one functional hsp47 gene (CBP2) and a pseudogene (pshsp47)". Gene 227 (2): 241–8. February 1999. doi:10.1016/S0378-1119(98)00592-7. PMID 10023073. 
  • "Cell surface colligin/Hsp47 associates with tetraspanin protein CD9 in epidermoid carcinoma cell lines". Journal of Cellular Biochemistry 73 (2): 248–58. May 1999. doi:10.1002/(SICI)1097-4644(19990501)73:2<248::AID-JCB11>3.0.CO;2-A. PMID 10227388. 
  • "Conformational requirements of collagenous peptides for recognition by the chaperone protein HSP47". The Journal of Biological Chemistry 275 (36): 27957–63. September 2000. doi:10.1074/jbc.M003026200. PMID 10862616. 
  • "Rheumatoid arthritis-related antigen 47kDa (RA-A47) is a product of colligin-2 and acts as a human HSP47". Journal of Bone and Mineral Metabolism 18 (6): 328–34. 2001. doi:10.1007/s007740070004. PMID 11052465. 
  • "Competitive recruitment of CBP and Rb-HDAC regulates UBF acetylation and ribosomal transcription". Molecular Cell 6 (5): 1059–66. November 2000. doi:10.1016/S1097-2765(00)00104-0. PMID 11106745. 
  • "Molecular cloning of a novel ubiquitin-like protein, UBIN, that binds to ER targeting signal sequences". Biochemical and Biophysical Research Communications 280 (2): 535–40. January 2001. doi:10.1006/bbrc.2000.4149. PMID 11162551. 
  • "TFIIH inhibits CDK9 phosphorylation during human immunodeficiency virus type 1 transcription". The Journal of Biological Chemistry 276 (48): 44633–40. November 2001. doi:10.1074/jbc.M107466200. PMID 11572868. 
  • "Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2". The Journal of Biological Chemistry 277 (9): 7029–36. March 2002. doi:10.1074/jbc.M108826200. PMID 11748222. 
  • "Induction of heat shock protein 47 synthesis by TGF-beta and IL-1 beta via enhancement of the heat shock element binding activity of heat shock transcription factor 1". Journal of Immunology 168 (10): 5178–83. May 2002. doi:10.4049/jimmunol.168.10.5178. PMID 11994473. 
  • "Collagens, collagen-binding heat shock protein 47 and transforming growth factor-beta 1 are induced in cicatricial pemphigoid: possible role(s) in dermal fibrosis". Cytokine 17 (6): 311–6. March 2002. doi:10.1006/cyto.2002.1020. PMID 12061838. 
  • "Type XXVI collagen, a new member of the collagen family, is specifically expressed in the testis and ovary". The Journal of Biological Chemistry 277 (40): 37678–84. October 2002. doi:10.1074/jbc.M205347200. PMID 12145293. 
  • "Functional linkage between the endoplasmic reticulum protein Hsp47 and procollagen expression in human vascular smooth muscle cells". The Journal of Biological Chemistry 277 (41): 38571–8. October 2002. doi:10.1074/jbc.M206689200. PMID 12163502. 

External links



Retrieved from "https://handwiki.org/wiki/index.php?title=Biology:Heat_shock_protein_47&oldid=3583765"