Biology:LATS2
 Generic protein structure example |
Large tumor suppressor kinase 2 (LATS2) is an enzyme that in humans is encoded by the LATS2 gene.[1][2]
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family and participates in the Hippo signaling pathway where it inactivates the effector proteins, YAP and WWTR1 (TAZ). The protein localizes to centrosomes during interphase and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a corepressor of androgen-responsive gene expression.[2]
References
- ↑ "Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts". Genomics 63 (2): 263–70. Apr 2000. doi:10.1006/geno.1999.6065. PMID 10673337.
- ↑ 2.0 2.1 "Entrez Gene: LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26524.
Further reading
- "Molecular cloning of a novel human protein kinase, kpm, that is homologous to warts/lats, a Drosophila tumor suppressor.". Oncogene 19 (27): 3101–9. 2000. doi:10.1038/sj.onc.1203659. PMID 10871863.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Lats2, a putative tumor suppressor, inhibits G1/S transition.". Oncogene 22 (28): 4398–405. 2003. doi:10.1038/sj.onc.1206603. PMID 12853976.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "The LATS2/KPM tumor suppressor is a negative regulator of the androgen receptor.". Mol. Endocrinol. 18 (8): 2011–23. 2005. doi:10.1210/me.2004-0065. PMID 15131260.
- "The centrosomal protein Lats2 is a phosphorylation target of Aurora-A kinase.". Genes Cells 9 (5): 383–97. 2005. doi:10.1111/j.1356-9597.2004.00732.x. PMID 15147269.
- "Putative tumor suppressor Lats2 induces apoptosis through downregulation of Bcl-2 and Bcl-x(L).". Exp. Cell Res. 298 (2): 329–38. 2004. doi:10.1016/j.yexcr.2004.04.031. PMID 15265683.
- "The Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1.". Oncogene 24 (12): 2076–86. 2005. doi:10.1038/sj.onc.1208445. PMID 15688006.
- "Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers.". Clin. Cancer Res. 11 (4): 1380–5. 2005. doi:10.1158/1078-0432.CCR-04-1773. PMID 15746036.
- "LATS2-Ajuba complex regulates gamma-tubulin recruitment to centrosomes and spindle organization during mitosis.". FEBS Lett. 580 (3): 782–8. 2006. doi:10.1016/j.febslet.2005.12.096. PMID 16413547.
- "A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors.". Cell 124 (6): 1169–81. 2006. doi:10.1016/j.cell.2006.02.037. PMID 16564011.
- "A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization.". Genes Dev. 20 (19): 2687–700. 2007. doi:10.1101/gad.1447006. PMID 17015431.
- "Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma.". Neurosci. Res. 56 (4): 450–8. 2007. doi:10.1016/j.neures.2006.09.006. PMID 17049657.
 |  |
