Biology:LEFTY2
 Generic protein structure example |
Left-right determination factor 2 (Lefty2) aka TGFB4 is a protein that is encoded by the LEFTY2 gene in humans.
[1]
Function
Lefty2 is a protein from the TGF-beta cytokine family of proteins and is sometimes referred to as TGFB-4.[2][3] It is secreted and plays a role in left-right asymmetry determination of organ systems during development. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs.
Lefty2 is also sometimes referred to as Endometrial Bleeding-Associated Factor (EBAF).[2] Some types of infertility have been associated with dysregulated expression of this gene in the endometrium and the protein may play a role in endometrial bleeding.
Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene.
References
- ↑ "Entrez Gene: Left-right determination factor 2". https://www.ncbi.nlm.nih.gov/gene/7044.
- ↑ 2.0 2.1 GeneCards Human Gene Database. "LEFTY2 Gene - GeneCards | LFTY2 Protein | LFTY2 Antibody" (in en). https://www.genecards.org/cgi-bin/carddisp.pl?gene=LEFTY2.
- ↑ "LEFTY2 left-right determination factor 2 [Homo sapiens (human) - Gene - NCBI"]. https://www.ncbi.nlm.nih.gov/gene/7044.
Further reading
- "Distinct tumor specific expression of TGFB4 (ebaf)*, a novel human gene of the TGF-beta superfamily". Front. Biosci. 2: a18–25. 1997. doi:10.2741/a158. PMID 9230066.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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