Biology:GDF10
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Growth differentiation factor 10 (GDF10) also known as bone morphogenetic protein 3B (BMP-3B) is a protein that in humans is encoded by the GDF10 gene.[1]
GDF10 belongs to the transforming growth factor beta superfamily that is closely related to bone morphogenetic protein-3 (BMP3). It plays a role in head formation and may have multiple roles in skeletal morphogenesis.[1][2] GDF10 is also known as BMP-3b, with GDF10 and BMP3 regarded as a separate subgroup within the TGF-beta superfamily.[1]
In mice, GDF10 mRNA is abundant in the brain, inner ear, uterus, prostate, neural tissues, blood vessels and adipose tissue with low expression in spleen and liver. It is also present in bone of both adults and neonatal mice.[1] Human GDF10 mRNA is found in the cochlea and lung of foetuses, and in testis, retina, pineal gland, and other neural tissues of adults.[3]
References
- ↑ 1.0 1.1 1.2 1.3 "Growth/differentiation factor-10: a new member of the transforming growth factor-beta superfamily related to bone morphogenetic protein-3". Growth Factors 12 (2): 99–109. 1995. doi:10.3109/08977199509028956. PMID 8679252.
- ↑ "Bone morphogenetic protein-3 family members and their biological functions". Front Biosci 9 (1–3): 1520–9. 2004. doi:10.2741/1355. PMID 14977563.
- ↑ "Comparative integromics on BMP/GDF family". Int J Mol Med 17 (5): 951–5. 2006. doi:10.3892/ijmm.17.5.951. PMID 16596286.
Further reading
- "New genetic associations detected in a host response study to hepatitis B vaccine.". Genes Immun. 11 (3): 232–8. 2010. doi:10.1038/gene.2010.1. PMID 20237496.
- "The family of bone morphogenetic proteins.". Kidney Int. 57 (6): 2207–14. 2000. doi:10.1046/j.1523-1755.2000.00081.x. PMID 10844590.
- "A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.". Am. J. Hum. Genet. 78 (1): 78–88. 2006. doi:10.1086/498851. PMID 16385451.
- "cDNA cloning and genomic structure of human bone morphogenetic protein-3B (BMP-3b).". Biochem. Biophys. Res. Commun. 223 (2): 304–10. 1996. doi:10.1006/bbrc.1996.0889. PMID 8670277.
- "An investigation into the human serum "interactome".". Electrophoresis 25 (9): 1289–98. 2004. doi:10.1002/elps.200405866. PMID 15174051.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2002. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The aberrant promoter methylation of BMP3b and BMP6 in malignant pleural mesotheliomas.". Oncol. Rep. 20 (5): 1265–8. 2008. doi:10.3892/or_00000139. PMID 18949431.
- "Hypoxia promotes the differentiated human articular chondrocyte phenotype through SOX9-dependent and -independent pathways.". J. Biol. Chem. 283 (8): 4778–86. 2008. doi:10.1074/jbc.M707729200. PMID 18077449.
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