Biology:Lupan-3beta,20-diol synthase

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Lupan-3β,20-diol synthase
Identifiers
EC number4.2.1.128
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Lupan-3β,20-diol synthase (EC 4.2.1.128, LUP1 (gene)) is an enzyme with systematic name (3S)-2,3-epoxy-2,3-dihydrosqualene hydro-lyase (lupan-3beta,20-diol forming).[1][2] This enzyme catalyses the following chemical reaction

lupan-3β,20-diol [math]\displaystyle{ \rightleftharpoons }[/math] (3S)-2,3-epoxy-2,3-dihydrosqualene + H2O

The reaction occurs in the reverse direction.

References

  1. "Arabidopsis thaliana LUP1 converts oxidosqualene to multiple triterpene alcohols and a triterpene diol". Organic Letters 2 (15): 2257–9. July 2000. doi:10.1021/ol006016b. PMID 10930257. 
  2. "Stereochemical course in water addition during LUP1-catalyzed triterpene cyclization". Organic Letters 8 (24): 5589–92. November 2006. doi:10.1021/ol062310d. PMID 17107079. 

External links