Biology:Lysine dehydrogenase
From HandWiki
lysine dehydrogenase | |||||||||
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Identifiers | |||||||||
EC number | 1.4.1.15 | ||||||||
CAS number | 68073-29-0 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a lysine dehydrogenase (EC 1.4.1.15) is an enzyme that catalyzes the chemical reaction
- L-lysine + NAD+ [math]\displaystyle{ \rightleftharpoons }[/math] 1,2-didehydropiperidine-2-carboxylate + NH3 + NADH + H+
Thus, the two substrates of this enzyme are L-lysine and NAD+, whereas its 4 products are 1,2-didehydropiperidine-2-carboxylate, NH3, NADH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-lysine:NAD+ oxidoreductase (deaminating, cyclizing).
References
- "L-Lysine dehydrogenase deficiency in a patient with congenital lysine intolerance". Nature 211 (5051): 854–5. 1966. doi:10.1038/211854a0. PMID 4291003.
Original source: https://en.wikipedia.org/wiki/Lysine dehydrogenase.
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