Biology:MAP4K1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Mitogen-activated protein kinase kinase kinase kinase 1 is a protein kinase that in humans is encoded by the MAP4K1 gene.[1] It is also known as HPK1 (Hematopoietic Progenitor Kinase 1). The protein has been shown to play a role in JNK activation.[2]
Interactions
MAP4K1 has been shown to interact with:
Optimization of inhibitors of MAP4K1 for upregulating the T cell receptor signaling pathway has produced at least one compound that exhibits antitumor activity in an EMT6 syngeneic mouse model, and is an area of ongoing research.[10]
References
- ↑ "Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade". Genes Dev 10 (18): 2251–64. Dec 1996. doi:10.1101/gad.10.18.2251. PMID 8824585.
- ↑ Chuang, HC; Wang, X; Tan, TH (2016). MAP4K Family Kinases in Immunity and Inflammation. Advances in Immunology. 129. 277–314. doi:10.1016/bs.ai.2015.09.006. ISBN 9780128047996.
- ↑ "B cell adaptor containing src homology 2 domain (BASH) links B cell receptor signaling to the activation of hematopoietic progenitor kinase 1". J. Exp. Med. 194 (4): 529–39. Aug 2001. doi:10.1084/jem.194.4.529. PMID 11514608.
- ↑ 4.0 4.1 4.2 "The germinal center kinase (GCK)-related protein kinases HPK1 and KHS are candidates for highly selective signal transducers of Crk family adapter proteins". Oncogene 17 (15): 1893–901. Oct 1998. doi:10.1038/sj.onc.1202108. PMID 9788432.
- ↑ 5.0 5.1 5.2 5.3 "Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase". Mol. Cell. Biol. 19 (2): 1359–68. Feb 1999. doi:10.1128/MCB.19.2.1359. PMID 9891069.
- ↑ 6.0 6.1 6.2 6.3 6.4 "Involvement of hematopoietic progenitor kinase 1 in T cell receptor signaling". J. Biol. Chem. 276 (22): 18908–14. Jun 2001. doi:10.1074/jbc.M101485200. PMID 11279207.
- ↑ "A novel src homology 3 domain-containing adaptor protein, HIP-55, that interacts with hematopoietic progenitor kinase 1". J. Biol. Chem. 274 (48): 33945–50. Nov 1999. doi:10.1074/jbc.274.48.33945. PMID 10567356.
- ↑ "Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytes". Oncogene 20 (14): 1703–14. Mar 2001. doi:10.1038/sj.onc.1204224. PMID 11313918.
- ↑ 9.0 9.1 "SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1". J. Biol. Chem. 272 (44): 27804–11. Oct 1997. doi:10.1074/jbc.272.44.27804. PMID 9346925.
- ↑ "Discovery and Optimization of Pyrazine Carboxamide AX3246, a Selective HPK1 Inhibitor". Journal of Medicinal Chemistry 68 (4): 4582–4595. Feb 2025. doi:10.1021/acs.jmedchem.4c02631. PMID 39928839.
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