Biology:MED29
From HandWiki
| Med29 | |||||||||
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| Identifiers | |||||||||
| Symbol | Med29 | ||||||||
| Pfam | PF11568 | ||||||||
| InterPro | IPR021018 | ||||||||
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Mediator of RNA polymerase II transcription subunit 29 (Med29) is a transcription suppressor that in humans is encoded by the MED29 gene.[1] It represents subunit MED29 of the Mediator complex.
Med29, along with Med11 and Med28 in mammals, is part of the core head-region of the Mediator complex. Med29 is the apparent orthologue of the Drosophila melanogaster Intersex protein (IXL), which interacts directly with, and functions as a transcriptional coactivator for, the DNA-binding transcription factor Doublesex, so it is likely that mammalian Med29 serves as a target for one or more DNA-binding transcriptional activators.[2]
See also
References
- ↑ "IXL, a new subunit of the mammalian Mediator complex, functions as a transcriptional suppressor.". Biochem Biophys Res Commun 325 (4): 1330–8. 2004. doi:10.1016/j.bbrc.2004.10.159. PMID 15555573.
- ↑ "The mammalian Mediator complex and its role in transcriptional regulation". Trends Biochem. Sci. 30 (5): 250–5. May 2005. doi:10.1016/j.tibs.2005.03.002. PMID 15896743.
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