Biology:MIR194-1

Short description: Non-coding RNA in the species Homo sapiens

Generic protein structure example

MicroRNA 194-1 is a non-coding RNA that in humans is encoded by the MIR194-1 gene.

Function

microRNAs (miRNAs) are short (20–24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Further reading

• "p53-responsive miR-194 inhibits thrombospondin-1 and promotes angiogenesis in colon cancers". Cancer Research 71 (24): 7490–7501. Dec 2011. doi:10.1158/0008-5472.CAN-11-1124. PMID 22028325. 
• "MicroRNA-194 inhibits epithelial to mesenchymal transition of endometrial cancer cells by targeting oncogene BMI-1". Molecular Cancer 10: 99. 2011. doi:10.1186/1476-4598-10-99. PMID 21851624. 
• "Inverse association between miR-194 expression and tumor invasion in gastric cancer". Annals of Surgical Oncology 19 (Suppl 3): S509–17. Jul 2012. doi:10.1245/s10434-011-1999-2. PMID 21845495. 
• "New microRNAs from mouse and human". RNA 9 (2): 175–179. Feb 2003. doi:10.1261/rna.2146903. PMID 12554859. 
• "MiR-194 regulates chondrogenic differentiation of human adipose-derived stem cells by targeting Sox5". PLOS ONE 7 (3): e31861. 2012. doi:10.1371/journal.pone.0031861. PMID 22396742. Bibcode: 2012PLoSO...731861X. 
• "Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development". Cancer Cell 18 (4): 367–381. Oct 2010. doi:10.1016/j.ccr.2010.09.005. PMID 20951946. 
• "Reduced accumulation of specific microRNAs in colorectal neoplasia". Molecular Cancer Research 1 (12): 882–891. Oct 2003. PMID 14573789. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.