Biology:MYLK3
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Myosin light chain kinase 3 also known as MYLK3, is an enzyme which in humans is encoded by the MYLK3 gene.[1][2]
Function
Phosphorylation of cardiac myosin heavy chains (see MYH7B) and light chains (see MYL2) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes.[3]
See also
References
- ↑ "Entrez Gene: MLCK MLCK protein". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=91807.
- ↑ "A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart". J. Clin. Invest. 117 (10): 2812–24. October 2007. doi:10.1172/JCI30804. PMID 17885681.
- ↑ "Identification of cardiac-specific myosin light chain kinase". Circ. Res. 102 (5): 571–80. March 2008. doi:10.1161/CIRCRESAHA.107.161687. PMID 18202317.
Further reading
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "A differentiation-dependent splice variant of myosin light chain kinase, MLCK1, regulates epithelial tight junction permeability.". J. Biol. Chem. 279 (53): 55506–13. 2005. doi:10.1074/jbc.M408822200. PMID 15507455.
- "Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression.". Am. J. Pathol. 166 (2): 409–19. 2005. doi:10.1016/S0002-9440(10)62264-X. PMID 15681825.
- "Distinct temporal-spatial roles for rho kinase and myosin light chain kinase in epithelial purse-string wound closure.". Gastroenterology 128 (4): 987–1001. 2005. doi:10.1053/j.gastro.2005.01.004. PMID 15825080.
- "Ca2+-calmodulin-dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK293 cells.". J. Physiol. 570 (Pt 2): 219–35. 2006. doi:10.1113/jphysiol.2005.097998. PMID 16284075.
- "Involvement of calmodulin and myosin light chain kinase in activation of mTRPC5 expressed in HEK cells.". Am. J. Physiol., Cell Physiol. 290 (4): C1031–40. 2006. doi:10.1152/ajpcell.00602.2004. PMID 16306123.
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560.
- "Myosin light chain kinase plays a role in the regulation of epithelial cell survival.". J. Cell Sci. 119 (Pt 11): 2269–81. 2007. doi:10.1242/jcs.02926. PMID 16723733.
- "A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart.". J. Clin. Invest. 117 (10): 2812–24. 2007. doi:10.1172/JCI30804. PMID 17885681.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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