Biology:Melanoma inhibitory activity

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Melanoma-derived growth regulatory protein is a protein that in humans is encoded by the MIA gene.

It is a marker for malignant melanoma.

Further reading

• "Structure and promoter analysis of the gene encoding the human melanoma-inhibiting protein MIA.". J. Biol. Chem. 271 (1): 490–5. 1996. doi:10.1074/jbc.271.1.490. PMID 8550608. 
• "The extracellular human melanoma inhibitory activity (MIA) protein adopts an SH3 domain-like fold.". EMBO J. 20 (3): 340–9. 2001. doi:10.1093/emboj/20.3.340. PMID 11157741. 
• "Structure of melanoma inhibitory activity protein, a member of a recently identified family of secreted proteins.". Proc. Natl. Acad. Sci. U.S.A. 98 (10): 5515–20. 2001. doi:10.1073/pnas.091601698. PMID 11331761. Bibcode: 2001PNAS...98.5515L. 
• "Solution structure and dynamics of melanoma inhibitory activity protein.". J. Biomol. NMR 22 (3): 211–23. 2002. doi:10.1023/A:1014961408029. PMID 11991352. 
• "Melanoma-inhibiting activity (MIA/CD-RAP) is expressed in a variety of malignant tumors of mainly neuroectodermal origin.". Anticancer Res. 22 (2A): 577–83. 2002. PMID 12014625. 
• "Cloning and characterization of the expression pattern of a novel splice product MIA (splice) of malignant melanoma-derived growth-inhibiting activity (MIA/CD-RAP) [corrected].". J. Invest. Dermatol. 119 (3): 562–9. 2002. doi:10.1046/j.1523-1747.2002.00501.x. PMID 12230496. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Upregulation of HMG1 leads to melanoma inhibitory activity expression in malignant melanoma cells and contributes to their malignancy phenotype.". Mol. Cell. Biol. 23 (8): 2991–8. 2003. doi:10.1128/MCB.23.8.2991-2998.2003. PMID 12665595. 
• "Macrophage-derived soluble factor enhances melanoma inhibitory activity expression by uveal melanoma cells in vitro.". Melanoma Res. 14 (2): 91–5. 2005. doi:10.1097/00008390-200404000-00003. PMID 15057037. 
• "Ultraviolet radiation induces release of MIA: a new mechanism for UVR-induced progression of melanoma.". Int. J. Oncol. 25 (1): 105–11. 2005. doi:10.3892/ijo.25.1.105. PMID 15201995. 
• "Functional role of MIA in melanocytes and early development of melanoma.". Oncogene 23 (36): 6115–24. 2005. doi:10.1038/sj.onc.1207797. PMID 15208686. 
• "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. 2005. doi:10.1110/ps.04682504. PMID 15340161. 
• "Inhibition of immunosuppressive effects of melanoma-inhibiting activity (MIA) by antisense techniques.". Int. J. Cancer 113 (1): 88–92. 2004. doi:10.1002/ijc.20549. PMID 15386421. 
• "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "Expression levels of melanoma inhibitory activity correlate with time to progression in patients with high-grade glioma.". Oncol. Rep. 12 (6): 1355–64. 2005. doi:10.3892/or.12.6.1355. PMID 15547763. 
• "Inhibition of melanoma inhibitory activity (MIA) expression in melanoma cells leads to molecular and phenotypic changes.". Pigment Cell Res. 18 (2): 92–101. 2005. doi:10.1111/j.1600-0749.2005.00212.x. PMID 15760338. 
• "Systematic search for gastric cancer-specific genes based on SAGE data: melanoma inhibitory activity and matrix metalloproteinase-10 are novel prognostic factors in patients with gastric cancer.". Oncogene 25 (17): 2546–57. 2006. doi:10.1038/sj.onc.1209279. PMID 16331256. 
• "Melanoma inhibiting activity protein (MIA), beta-2 microglobulin and lactate dehydrogenase (LDH) in metastatic melanoma.". Anticancer Res. 27 (1B): 595–9. 2007. PMID 17348447.