Biology:Methylthioribulose 1-phosphate dehydratase
From HandWiki
methylthioribulose 1-phosphate dehydratase | |||||||||
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Identifiers | |||||||||
EC number | 4.2.1.109 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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The enzyme methylthioribulose 1-phosphate dehydratase (EC .2.1.109) catalyzes the chemical reaction
- 5-(methylsulfanyl)-D)ribulose 1-phosphate [math]\displaystyle{ \rightleftharpoons }[/math] 5-(methylthio)-2,3-dioxopentyl phosphate + H2
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 5-methyl-5-thio-D-ribulose-1-phosphate 4-hydro-lyase [5-(methylthio)-2,3-dioxopentyl-phosphate-forming]. Other names in common use include 1-PMT-ribulose dehydratase, and S-methyl-5-thio-D-ribulose-1-phosphate hydro-lyase. This enzyme participates in methionine metabolism.
References
- ↑ Kang, W; Hong, S. H.; Lee, H. M.; Kim, N. Y.; Lim, Y. C.; Le Le, T. M.; Lim, B; Kim, H. C. et al. (2014). "Structural and biochemical basis for the inhibition of cell death by APIP, a methionine salvage enzyme". Proceedings of the National Academy of Sciences 111 (1): E54-61. doi:10.1073/pnas.1308768111. PMID 24367089. Bibcode: 2014PNAS..111E..54K.
- "Intermediates in the conversion of 5'-S-methylthioadenosine to methionine in Klebsiella pneumoniae". J. Biol. Chem. 263 (20): 9598–606. 1988. doi:10.1016/S0021-9258(19)81558-2. PMID 2838472.
- "The methionine salvage pathway in Klebsiella pneumoniae and rat liver. Identification and characterization of two novel dioxygenases". J. Biol. Chem. 270 (7): 3147–53. 1995. doi:10.1074/jbc.270.7.3147. PMID 7852397.
Original source: https://en.wikipedia.org/wiki/Methylthioribulose 1-phosphate dehydratase.
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