Biology:Miltiradiene synthase
From HandWiki
| Miltiradiene synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.2.3.131 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Miltiradiene synthase (EC 4.2.3.131, SmMDS, SmiKSL) is an enzyme with systematic name (+)-copaly-diphosphate diphosphate-lyase (cyclizing, miltiradiene-forming).[1][2] This enzyme catalyses the following chemical reaction
- (+)-copalyl diphosphate [math]\displaystyle{ \rightleftharpoons }[/math] miltiradiene + diphosphate
This enzyme is isolated from the plant Selaginella moellendorffii.
References
- ↑ "A functional genomics approach to tanshinone biosynthesis provides stereochemical insights". Organic Letters 11 (22): 5170–3. November 2009. doi:10.1021/ol902051v. PMID 19905026.
- ↑ "Enzymatic (13)C labeling and multidimensional NMR analysis of miltiradiene synthesized by bifunctional diterpene cyclase in Selaginella moellendorffii". The Journal of Biological Chemistry 286 (50): 42840–7. December 2011. doi:10.1074/jbc.m111.302703. PMID 22027823.
External links
- Miltiradiene+synthase at the US National Library of Medicine Medical Subject Headings (MeSH)
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