Biology:Molybdopterin synthase sulfurtransferase
From HandWiki
| Molybdopterin synthase sulfurtransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.8.1.11 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Molybdopterin synthase sulfurtransferase (EC 2.8.1.11, adenylyltransferase and sulfurtransferase MOCS3, Cnx5 (gene), molybdopterin synthase sulfurylase) is an enzyme with systematic name persulfurated L-cysteine desulfurase:(molybdopterin-synthase sulfur-carrier protein)-Gly-Gly sulfurtransferase.[1][2][3][4] This enzyme catalyses the following chemical reaction
- [molybdopterin-synthase sulfur-carrier protein]-Gly-Gly-AMP + [cysteine desulfurase]-S-sulfanyl-L-cysteine [math]\displaystyle{ \rightleftharpoons }[/math] AMP + [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH2-C(O)SH + cysteine desulfurase
The enzyme transfers sulfur to form a thiocarboxylate moiety on the C-terminal glycine of the small subunit of molybdopterin synthase.
References
- ↑ "Molybdenum cofactor biosynthesis in humans: identification of a persulfide group in the rhodanese-like domain of MOCS3 by mass spectrometry". Biochemistry 44 (21): 7912–20. May 2005. doi:10.1021/bi0503448. PMID 15910006.
- ↑ "A sulfurtransferase is required in the transfer of cysteine sulfur in the in vitro synthesis of molybdopterin from precursor Z in Escherichia coli". The Journal of Biological Chemistry 276 (25): 22024–31. June 2001. doi:10.1074/jbc.M102072200. PMID 11290749.
- ↑ "Crystal structure of YnjE from Escherichia coli, a sulfurtransferase with three rhodanese domains". Protein Science 18 (12): 2480–91. December 2009. doi:10.1002/pro.260. PMID 19798741.
- ↑ "The identification of a novel protein involved in molybdenum cofactor biosynthesis in Escherichia coli". The Journal of Biological Chemistry 286 (41): 35801–12. October 2011. doi:10.1074/jbc.M111.282368. PMID 21856748.
External links
- Molybdopterin+synthase+sulfurtransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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