Biology:Mycothione reductase
From HandWiki
mycothione reductase | |||||||||
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Identifiers | |||||||||
EC number | 1.8.1.15 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a mycothione reductase (EC 1.8.1.15) is an enzyme that catalyzes the chemical reaction
- mycothione + NAD(P)H + H + [math]\displaystyle{ \rightleftharpoons }[/math] 2 mycothiol + NADP+
in M. tuberculosis and other actinomycetes.
The 2 substrates of this enzyme are mycothiol and NADPH, whereas 2 molecules of mycothione and NADP+ are formed as products.
This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is mycothiol:NAD(P)+ oxidoreductase. This enzyme is also called mycothiol-disulfide reductase.
References
- "Expression, purification, and characterization of Mycobacterium tuberculosis mycothione reductase". Biochemistry 38 (36): 11827–33. 1999. doi:10.1021/bi991025h. PMID 10512639.
- "Mycobacterium tuberculosis mycothione reductase: pH dependence of the kinetic parameters and kinetic isotope effects". Biochemistry 40 (17): 5119–26. 2001. doi:10.1021/bi0029144. PMID 11318633.
Original source: https://en.wikipedia.org/wiki/Mycothione reductase.
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