Biology:NCDN
 Generic protein structure example |
Neurochondrin (also known as its murine homologue, Norbin) is a protein that in humans is encoded by the NCDN gene.[1][2]
This gene encodes a leucine-rich cytoplasmic protein, which is highly similar to a mouse protein norbin that negatively regulates Ca/calmodulin-dependent protein kinase II phosphorylation and may be essential for spatial learning processes. Several alternatively spliced transcript variants of this gene have been described.[2]
Norbin can modulate signaling activity and expression of metabotropic glutamate receptor 5; modulating mice with targeted deletion of NCDN in the brain have phenotypic traits usually found in the rodent models of schizophrenia, including disruptions in prepulse inhibition.[3] Furthermore, norbin protein expression is altered in the schizophrenia brain.[4]
Neurochondrin proteins induce hydroxyapatite resorptive activity in bone marrow cells resistant to bafilomycin A1, an inhibitor of macrophage- and osteoclast-mediated resorption. Expression of the gene is localised to chondrocyte, osteoblast, and osteocyte in the bone and to the hippocampus and Purkinje cell layer of cerebellum in the brain.[5]
References
- ↑ "Expression of neurochondrin in the developing and adult mouse brain". Development Genes and Evolution 214 (4): 206–9. Apr 2004. doi:10.1007/s00427-004-0396-2. PMID 15007648.
- ↑ 2.0 2.1 "Entrez Gene: NCDN neurochondrin". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23154.
- ↑ "Norbin is an endogenous regulator of metabotropic glutamate receptor 5 signaling". Science 326 (5959): 1554–7. Dec 2009. doi:10.1126/science.1178496. PMID 20007903. Bibcode: 2009Sci...326.1554W.
- ↑ "Alterations of mGluR5 and its endogenous regulators Norbin, Tamalin and Preso1 in schizophrenia: towards a model of mGluR5 dysregulation". Acta Neuropathologica 130 (1): 119–29. Jul 2015. doi:10.1007/s00401-015-1411-6. PMID 25778620. http://ro.uow.edu.au/cgi/viewcontent.cgi?article=1538&context=ihmri.
- ↑ "Induction of hydroxyapatite resorptive activity in bone marrow cell populations resistant to bafilomycin A1 by a factor with restricted expression to bone and brain, neurochondrin". Biochim. Biophys. Acta 1450 (1): 92–98. 1999. doi:10.1016/s0167-4889(99)00039-7. PMID 10231559.
Further reading
- "Neurochondrin negatively regulates CaMKII phosphorylation, and nervous system-specific gene disruption results in epileptic seizure". The Journal of Biological Chemistry 280 (21): 20503–8. May 2005. doi:10.1074/jbc.M414033200. PMID 15790563.
- "Targeted disruption of the neurochondrin/norbin gene results in embryonic lethality". Biochemical and Biophysical Research Communications 310 (4): 1219–26. Oct 2003. doi:10.1016/j.bbrc.2003.09.153. PMID 14559245.
- "The Chediak-Higashi protein interacts with SNARE complex and signal transduction proteins". Molecular Medicine 8 (1): 56–64. Jan 2002. doi:10.1007/bf03402003. PMID 11984006.
- "Semaphorin 4C, a transmembrane semaphorin, [corrected] associates with a neurite-outgrowth-related protein, SFAP75". Biochemical and Biophysical Research Communications 280 (1): 237–43. Jan 2001. doi:10.1006/bbrc.2000.4080. PMID 11162505.
- "Corrigendum to 'Molecular cloning and expression of human neurochondrin-1 and -2'(1)". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1490 (3): 367–8. Feb 2000. doi:10.1016/s0167-4781(99)00236-5. PMID 10684983.
- "Molecular cloning and expression of human neurochondrin-1 and -2". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1446 (3): 397–402. Sep 1999. doi:10.1016/s0167-4781(99)00120-7. PMID 10524216.
- "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research 5 (1): 31–9. Feb 1998. doi:10.1093/dnares/5.1.31. PMID 9628581.
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