Biology:Nicastrin
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Nicastrin, also known as NCSTN, is a protein that in humans is encoded by the NCSTN gene.[1][2][3]
Function
Nicastrin (abbreviated NCT) is a protein that is part of the gamma secretase protein complex, which is one of the proteases involved in processing amyloid precursor protein (APP) to the short Alzheimer's disease-associated peptide amyloid beta. The other proteins in the complex are PSEN1 (presenilin-1), which is the catalytically active component of the complex, APH-1 (anterior pharynx-defective 1), and PEN-2 (presenilin enhancer 2).[4] Nicastrin itself is not catalytically active, but instead promotes the maturation and proper trafficking of the other proteins in the complex, all of which undergo significant post-translational modification before becoming active in the cell.[5] Nicastrin has also been identified as a regulator of neprilysin, an enzyme involved in the degradation of amyloid beta fragment.[6]
History
The protein was named after the Italian country Nicastro, reflecting the fact that Alzheimer's disease was described in 1963 after studying descendants of an extended family originating in the country of Nicastro that had familial Alzheimer's disease (FAD).[7]
Interactions
Nicastrin has been shown to interact with PSEN1[8][9][10][11][12] and PSEN2.[8][12]
References
- ↑ "Entrez Gene: NCSTN nicastrin". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23385.
- ↑ "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Research 3 (5): 321–9, 341–54. Oct 1996. doi:10.1093/dnares/3.5.321. PMID 9039502.
- ↑ "Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing". Nature 407 (6800): 48–54. Sep 2000. doi:10.1038/35024009. PMID 10993067. Bibcode: 2000Natur.407...48Y.
- ↑ "Assembly, trafficking and function of gamma-secretase". Neuro-Degenerative Diseases 3 (4–5): 275–83. 2006. doi:10.1159/000095267. PMID 17047368. https://epub.ub.uni-muenchen.de/16592/1/10_1159_000095267.pdf.
- ↑ "Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components". The Journal of Biological Chemistry 280 (17): 17020–6. Apr 2005. doi:10.1074/jbc.M409467200. PMID 15711015.
- ↑ "Neprilysin activity and expression are controlled by nicastrin". Journal of Neurochemistry 97 (4): 1052–6. May 2006. doi:10.1111/j.1471-4159.2006.03822.x. PMID 16606360.
- ↑ "Familial Alzheimer's disease". Neurology 13 (10): 811–24. Oct 1963. doi:10.1212/wnl.13.10.811. PMID 14066996.
- ↑ 8.0 8.1 "Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing". Nature 407 (6800): 48–54. Sep 2000. doi:10.1038/35024009. PMID 10993067. Bibcode: 2000Natur.407...48Y.
- ↑ "Nicalin and its binding partner Nomo are novel Nodal signaling antagonists". The EMBO Journal 23 (15): 3041–50. Aug 2004. doi:10.1038/sj.emboj.7600307. PMID 15257293.
- ↑ "Functional gamma-secretase complex assembly in Golgi/trans-Golgi network: interactions among presenilin, nicastrin, Aph1, Pen-2, and gamma-secretase substrates". Neurobiology of Disease 14 (2): 194–204. Nov 2003. doi:10.1016/S0969-9961(03)00123-2. PMID 14572442.
- ↑ "APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes". The Journal of Biological Chemistry 278 (9): 7374–80. Feb 2003. doi:10.1074/jbc.M209499200. PMID 12471034.
- ↑ 12.0 12.1 "Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch". The Journal of Biological Chemistry 277 (47): 45013–9. Nov 2002. doi:10.1074/jbc.M208164200. PMID 12297508.
External links
- nicastrin+protein at the US National Library of Medicine Medical Subject Headings (MeSH)
![]() | Original source: https://en.wikipedia.org/wiki/Nicastrin.
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