Biology:O-phospho-L-serine—tRNA ligase
From HandWiki
| O-Phospho-L-serine—tRNA ligase | |||||||||
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| Identifiers | |||||||||
| EC number | 6.1.1.27 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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O-phospho-L-serine—tRNA ligase (EC 6.1.1.27, O-phosphoseryl-tRNA ligase, non-canonical O-phosphoseryl-tRNA synthetase, SepRS) is an enzyme with systematic name O-phospho-L-serine:tRNACys ligase (AMP-forming).[1][2] This enzyme catalyses the following chemical reaction:
- ATP + O-phospho-L-serine + tRNACys [math]\displaystyle{ \rightleftharpoons }[/math] AMP + diphosphate + O-phospho-L-seryl-tRNACys
In organisms like Archaeoglobus fulgidus, this enzyme ligates O-phosphoserine to tRNACys.
References
- ↑ "Structural insights into the first step of RNA-dependent cysteine biosynthesis in archaea". Nature Structural & Molecular Biology 14 (4): 272–9. April 2007. doi:10.1038/nsmb1219. PMID 17351629.
- ↑ "Redundant synthesis of cysteinyl-tRNACys in Methanosarcina mazei". The Journal of Biological Chemistry 283 (32): 22007–17. August 2008. doi:10.1074/jbc.M801839200. PMID 18559341.
External links
- O-phospho-L-serine—tRNA+ligase at the US National Library of Medicine Medical Subject Headings (MeSH)
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