Biology:Orotate reductase (NADPH)
From HandWiki
Short description: Enzyme class
| orotate reductase (NADPH) | |||||||||
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| Identifiers | |||||||||
| EC number | 1.3.1.15 | ||||||||
| CAS number | 37255-27-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, an orotate reductase (NADPH) (EC 1.3.1.15) is an enzyme that catalyzes the chemical reaction
- (S)-dihydroorotate + NADP+ [math]\displaystyle{ \rightleftharpoons }[/math] orotate + NADPH + H+
Thus, the two substrates of this enzyme are (S)-dihydroorotate and NADP+, whereas its 3 products are orotate, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-dihydroorotate:NADP+ oxidoreductase. Other names in common use include orotate reductase, dihydroorotate dehydrogenase, dihydro-orotic dehydrogenase, L-5,6-dihydro-orotate:NAD+ oxidoreductase, and orotate reductase (NADPH). It has one cofactor, FAD.
References
- "Two functionally different dihydroorotic dehydrogenases in bacteria". J. Bacteriol. 91 (6): 2251–6. 1966. PMID 4380263.
- "Properties of triphosphopyridine nucleotide-linked dihydroorotic dehydrogenase". J. Biol. Chem. 237: 2018–2024. 1962. PMID 13923427.
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