Biology:Peptidyl-glutamate 4-carboxylase
From HandWiki
| Peptidyl-glutamate 4-carboxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 4.1.1.90 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Peptidyl-glutamate 4-carboxylase (EC 4.1.1.90, vitamin K-dependent carboxylase, gamma-glutamyl carboxylase) is an enzyme with systematic name peptidyl-glutamate 4-carboxylase (2-methyl-3-phytyl-1,4-naphthoquinone-epoxidizing).[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction
- peptidyl-4-carboxyglutamate + 2,3-epoxyphylloquinone + H2O [math]\displaystyle{ \rightleftharpoons }[/math] peptidyl-glutamate + CO2 + O2 + phylloquinone
The enzyme can use various vitamin-K derivatives, including menaquinone.
References
- ↑ "Vitamin K and energy transduction: a base strength amplification mechanism". Science 269 (5231): 1684–91. September 1995. doi:10.1126/science.7569894. PMID 7569894.
- ↑ "Vitamin K-dependent biosynthesis of gamma-carboxyglutamic acid". Blood 93 (6): 1798–808. March 1999. doi:10.1182/blood.V93.6.1798.406k22_1798_1808. PMID 10068650.
- ↑ "Brønsted analysis reveals Lys218 as the carboxylase active site base that deprotonates vitamin K hydroquinone to initiate vitamin K-dependent protein carboxylation". Biochemistry 45 (44): 13239–48. November 2006. doi:10.1021/bi0609523. PMID 17073445.
- ↑ "Reaction mechanism of the vitamin K-dependent glutamate carboxylase: a computational study". The Journal of Physical Chemistry B 111 (44): 12883–7. November 2007. doi:10.1021/jp0738208. PMID 17935315.
- ↑ "The stereochemistry of hydrogen abstraction in vitamin K-dependent carboxylation". The Journal of Biological Chemistry 259 (24): 15010–2. December 1984. PMID 6150930.
- ↑ "Vitamin K dependent carboxylation: determination of the stereochemical course using 4-fluoroglutamyl-containing substrate". Biochemistry 30 (43): 10506–12. October 1991. doi:10.1021/bi00107a020. PMID 1931973.
External links
- Peptidyl-glutamate+4-carboxylase at the US National Library of Medicine Medical Subject Headings (MeSH)
 |  |
