Biology:Petasites

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Short description: Genus of flowering plants in the daisy family Asteraceae

Petasites
Petasites hybridus inflorescence - Keila.jpg
Petasites hybridus
Scientific classification e
Kingdom: Plantae
Clade: Tracheophytes
Clade: Angiosperms
Clade: Eudicots
Clade: Asterids
Order: Asterales
Family: Asteraceae
Subfamily: Asteroideae
Tribe: Senecioneae
Genus: Petasites
Mill.
Synonyms[1][2]
  • Nardosmia Cass.
  • Petasitis Mill.
Petasites japonicus

Petasites is a genus of flowering plants in the sunflower family, Asteraceae,[3] that are commonly referred to as butterburs[4][5][6] and coltsfoots.[7] They are perennial plants with thick, creeping underground rhizomes and large rhubarb-like leaves during the growing season. Most species are native to Asia or southern Europe.

Taxonomy

The genus name is derived from the Greek word πέτασος petasos, from the plant's broad leaves resembling a wide-brimmed hat.[8]

Species

Accepted species[1][3]
  • Petasites albus – white butterbur – Europe, Algeria, Turkey, Caucasus, India
  • Petasites fominii – Republic of Georgia
  • Petasites formosanus – Taiwan
  • Petasites frigidus – Arctic butterbur or Arctic sweet coltsfoot – Scandinavia, Mongolia, Canada, northern USA
  • Petasites hybridus – common butterbur – Europe, Mediterranean
  • Petasites japonicus – giant butterbur, fuki – China, Japan, Korea
  • Petasites kablikianus – southeastern Europe from Poland to Albania
  • Petasites kamengicus – Arunachal Pradesh
  • Petasites paradoxus – central + southwestern Europe from Spain to Poland
  • Petasites pyrenaicus syn. Petasites fragrans - winter heliotrope - from Azores to Ireland + Tunisia
  • Petasites radiatus – Mongolia
  • Petasites rubellus – Mongolia, Manchuria, Korea
  • Petasites sibiricus – Siberia
  • Petasites spurius – Europe, Siberia, Caucasus, Central Asia
  • Petasites tatewakianus – Siberia, Russian Far East, northeastern China
  • Petasites tricholobus – China, Vietnam, Himalayas
  • Petasites versipilus – Sichuan, Yunnan
Species of hybrid origin[1]
  • Petasites × vitifolius
Species formerly included[1]

Petasites glacialis (Ledeb.) Polunin - Endocellion glaciale (Ledeb.) Toman

Characteristics

The short spikes of flowers are produced just before the leaves in late winter (e.g. Petasites fragrans[4]) or spring, emerging with only a few elongated basal bracts and are usually green, flesh coloured or dull white depending on the species. It is dioecious, with male and female flowers borne on separate plants.[9]

Butterbur can be found in parts of Asia such as Korea, China , and Japan , as well as Europe and North America.[10][11] They prefer moist environments such as riverbanks, marshes and ditches.[7][12][13][14]

Petasites is closely related to the genera Tussilago and Senecio.

Medicinal uses

Butterbur has been used for over 2000 years to treat a variety of ailments including fever, lung disease, spasms, and pain.[12] Currently, butterbur extract is used for migraine prevention and treatment of allergic rhinitis, which have the most evidence for its effectiveness.[12][15][16]

Migraine

Some butterbur species contain the chemicals petasin and isopetasin which are believed to have potential benefits in treating migraines.[11] High concentrations of petasin occur in both butterbur root and leaves, with the leaves containing lower levels of the toxic chemical.[17] Butterbur extracts have been reported to be effective in reducing frequency and severity of migraine headaches.[11][12][15][18] Several double-blind studies have shown that high doses of Petasites hybridus" extract, containing petasin and/or isopetasin, are effective both in preventing and in relieving migraine, with the best results in groups taking the higher dose of the supplement.[11][18] Although mainly well tolerated, the adverse effects of butterbur reported in clinical trials include mainly gastrointestinal problems, such as nausea, flatulence, and belching.[19][18] In 2015, the American Academy of Neurology withdrew its original endorsement of butterbur due to safety concerns.[15] However, the Canadian Headache Society still recommends its use in migraine prevention for a selected number of patients based on their clinical features and co-existing disorders.[20]

Hay fever or allergic rhinitis

Additionally, a study showed butterbur extract to be an effective treatment for hay fever without the sedative effect of the antihistamine cetirizine, if taken four times daily.[21] Butterbur was also shown to be comparably effective as fexofenadine when compared to placebo for reducing symptoms of allergic rhinitis.[22]

Risks

Butterbur extracts may contain harmful components called pyrrolizidine alkaloids if the preparations are not carefully and fully purified.[11] The concentration of the toxic alkaloids is often highest in the rhizomes and lowest in the leaves, and may vary depending on where the plants are grown.[17] These chemicals are toxic to the liver and may cause cancers.[23][24] Thus, due to the potential for contamination, taking butterbur supplements is not recommended during pregnancy or breastfeeding.[19] Some sources say it is safe practice to consume butterbur extract that has been prepared by a reputable laboratory.[11] Other sources say no butterbur product is safe: "The cases of liver toxicity appear to have occurred with extracts of butterbur where the pyrrolizidine alkaloids had been removed and only small amounts remained. There is some evidence that other constituents found in butterbur such as the sesquiterpene constituents for example petasin may be implicated in the liver toxicity".[25][unreliable source?]

Long-term health effects and interaction of butterbur with other drugs have not been well documented. However, it can theoretically interact with certain blood pressure and heart medications, as well as with drugs that can induce a liver enzyme called CYP3A4 (i.e. St. John's wort, carbamazepine, phenytoin, rifampin); this interaction can potentially lead to increased concentration of the toxic alkaloids.[19]

References

  1. ↑ 1.0 1.1 1.2 1.3 Flann, C., ed (2009). "Petasites Mill.". http://dixon.iplantcollaborative.org/CompositaeWeb/default.aspx?Page=NameDetails&TabNum=0&NameId=e990ca5d-1326-4a80-a702-0e12916cb02a. 
  2. ↑ "Petasites Mill.". Plants of the World Online. Royal Botanic Gardens, Kew. 2023. https://powo.science.kew.org/taxon/urn:lsid:ipni.org:names:329075-2#synonyms. 
  3. ↑ 3.0 3.1 "Petasites Mill.". World Flora Consortium. 2023. http://www.worldfloraonline.org/taxon/wfo-4000028919. 
  4. ↑ 4.0 4.1 Stace, C. A. (2010). New Flora of the British Isles (Third ed.). Cambridge, U.K.: Cambridge University Press. ISBN 9780521707725. 
  5. ↑ Miller, Philip. 1754. Gardeners Dictionary...Abridged...fourth edition page 1056.
  6. ↑ Tropicos, Petasites Mill.
  7. ↑ 7.0 7.1 Petasites. Flora of North America. Volume 20, Page 635. efloras.org.
  8. ↑ "Butterbur". Drugs.com. 14 February 2022. https://www.drugs.com/npp/butterbur.html. 
  9. ↑ Desjardins, Stuart D.; Hoare, Arthur G.; Stace, Clive A. (2016). "A new natural hybrid in the genus Petasites: P. japonicus × P. pyrenaicus (Asteraceae)". New Journal of Botany 6 (2–3): 64–70. doi:10.1080/20423489.2016.1271383. https://figshare.com/articles/journal_contribution/4668331. 
  10. ↑ "Missouri Botanical Garden". http://www.missouribotanicalgarden.org/PlantFinder/PlantFinderDetails.aspx?kempercode=a645. 
  11. ↑ 11.0 11.1 11.2 11.3 11.4 11.5 Sun-Edelstein, Christina (March 2011). "Alternative Headache Treatments: Nutraceuticals, Behavioral and Physical Treatments". Headache 51 (3): 469–483. doi:10.1111/j.1526-4610.2011.01846.x. PMID 21352222. 
  12. ↑ 12.0 12.1 12.2 12.3 Sutherland, Anna; Sweet, Burgunda (May 2010). "Butterbur: An alternative therapy for migraine prevention". American Journal of Health-System Pharmacy 67 (9): 705–711. doi:10.2146/ajhp090136. PMID 20410544. 
  13. ↑ Petasites. Flora of China. Volume 20-21, Page 461. efloras.org.
  14. ↑ Altervista Flora Italiana genere Petasites
  15. ↑ 15.0 15.1 15.2 Holland, S.; Silberstein, S.D.; Freitag, F.; Dodick, D.W.; Argoff, C.; Ashman, E. (2012). "Evidence-based guideline update: NSAIDs and other complementary treatments for episodic migraine prevention in adults: [RETIRED]". Neurology 78 (17): 1346–1353. doi:10.1212/WNL.0b013e3182535d0c. PMID 22529203. PMC 3335449. https://n.neurology.org/content/78/17/1346. 
  16. ↑ Kaufeler, Robert; Polasek, Wolfgang; Brattstrom, Axel; Koetter, Uwe (March 2006). "Efficacy and Safety of Butterbur Herbal Extract Ze 339 in Seasonal Allergic Rhinitis: Postmarketing Surveillance Study". Advances in Therapy 23 (2): 373–384. doi:10.1007/bf02850143. PMID 16751170. 
  17. ↑ 17.0 17.1 Taylor, Frederick (March 2011). "Nutraceuticals and Headache: The Biological Basis". Headache 51 (3): 484–501. doi:10.1111/j.1526-4610.2011.01847.x. PMID 21352223. 
  18. ↑ 18.0 18.1 18.2 "Petasites hybridus root (butterbur) is an effective preventive treatment for migraine". Neurology 63 (12): 2240–4. December 2004. doi:10.1212/01.wnl.0000147290.68260.11. PMID 15623680. 
  19. ↑ 19.0 19.1 19.2 "Butterbur". http://online.factsandcomparisons.com/MonoDisp.aspx?monoID=fandc-np5066&quick=237777%7c20&search=237777%7c20&isstemmed=True&NDCmapping=-1&fromTop=true. 
  20. ↑ Pringsheim, Tamara; Davenport, Jeptha; Mackie, Gordon (March 2012). "Canadian Headache Society Guideline for Migraine Prophylaxis". Canadian Journal of Neurological Sciences 39 (2): S1–59. PMID 22683887. 
  21. ↑ Schapowal, A.Schapowal A; Petasites Study, Group (19 January 2002). "Randomised controlled trial of butterbur and cetirizine for treating seasonal allergic rhinitis". BMJ 324 (7330): 144–6. doi:10.1136/bmj.324.7330.144. PMID 11799030. 
  22. ↑ Schapowal, Andreas (2005). "Treating Intermittent Allergic Rhinitis: A Prospective, Randomized, Placebo and Antihistamine-controlled Study of Butterbur Extract Ze 339". Phytotherapy Research 19 (6): 530–537. doi:10.1002/ptr.1705. PMID 16114089. 
  23. ↑ Maxim Hirono I., Mori H., Yamada K. "Carcinogenic activity of petasitenine, a new pyrrolizidine alkaloid isolated from Petasites" Journal of the National Cancer Institute 1977 58:4 (1155-1157)
  24. ↑ Smith, LW; Culvenor, CC (1981). "Plant sources of hepatotoxic pyrrolizidine alkaloids". Journal of Natural Products 44 (2): 129–52. doi:10.1021/np50014a001. PMID 7017073. 
  25. ↑ "Butterbur extract supplement benefit, allergy, asthma, and migraine headache". http://www.raysahelian.com/butterbur.html. 

External links

Wikidata ☰ Q830156 entry



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