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In enzymology, a phosphomannomutase (EC is an enzyme that catalyzes the chemical reaction

alpha-D-mannose 1-phosphate [math]\rightleftharpoons[/math] D-mannose 6-phosphate

Hence, this enzyme has one substrate, alpha-D-mannose 1-phosphate, and one product, D-mannose 6-phosphate.

This enzyme belongs to the family of isomerases, specifically the phosphotransferases (phosphomutases), which transfer phosphate groups within a molecule. The systematic name of this enzyme class is alpha-D-mannose 1,6-phosphomutase. Other names in common use include mannose phosphomutase, phosphomannose mutase, and D-mannose 1,6-phosphomutase. This enzyme participates in fructose and mannose metabolism. It has 2 cofactors: D-glucose 1,6-bisphosphate, and D-Mannose 1,6-bisphosphate.

Structural studies[edit]

As of late 2007, 18 structures have been solved for this class of enzymes, with PDB accession codes 1K2Y, 1WQA, 2AMY, 2F7L, 2FKF, 2FKM, 2FUC, 2FUE, 2H4L, 2H5A, 2I54, 2I55, and 2Q4R.


  • "Phosphomannomutase and phosphoglucomutase in developing Cassia corymbosa seeds". Phytochemistry 18 (7): 1147–1150. 1979. doi:10.1016/0031-9422(79)80123-5. was the original source. Read more.