Biology:Precorrin-8X methylmutase
From HandWiki
| precorrin-8X methylmutase | |||||||||
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| Identifiers | |||||||||
| EC number | 5.4.99.61 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a precorrin-8X methylmutase (EC 5.4.99.61) is an enzyme that catalyzes the chemical reaction
- precorrin-8X [math]\displaystyle{ \rightleftharpoons }[/math] hydrogenobyrinate
Hence, this enzyme has one substrate, precorrin 8X, and one product, hydrogenobyrinate.
This enzyme belongs to the family of isomerases, specifically those intramolecular transferases transferring other groups. The systematic name of this enzyme class is precorrin-8X 11,12-methylmutase. Other names in common use include precorrin isomerase, hydrogenobyrinic acid-binding protein and CobH. This enzyme is part of the biosynthetic pathway to cobalamin (vitamin B12) in aerobic bacteria.
See also
Structural studies
As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1F2V, 1I1H, 1OU0, 1V9C, 2AFR, and 2AFV.
References
- ↑ Shipman, L. W.; Li, D.; Roessner, C. A.; Scott, A. I.; Sacchettini, J. C. (2001). "Crystal structure of precorrin-8x methyl mutase". Structure 9 (7): 587–596. doi:10.1016/s0969-2126(01)00618-9. PMID 11470433.
- Blanche F; Couder, M; Famechon, A; Debussche, L; Cameron, B; Crouzet, J; Blanche, F (1992). "The final step in the biosynthesis of hydrogenobyrinic acid is catalyzed by the cobH gene product with precorrin-8x as the substrate". J. Bacteriol. 174 (3): 1043–9. doi:10.1128/JB.174.3.1043-1049.1992. PMID 1732194.
- "Characterization of the cobalamin (vitamin B12) biosynthetic genes of Salmonella typhimurium". J. Bacteriol. 175 (11): 3303–16. 1993. doi:10.1128/jb.175.11.3303-3316.1993. PMID 8501034.
- "Expression of 9 Salmonella typhimurium enzymes for cobinamide synthesis. Identification of the 11-methyl and 20-methyl transferases of corrin biosynthesis". FEBS Lett. 301 (1): 73–8. 1992. doi:10.1016/0014-5793(92)80213-Z. PMID 1451790.
- "Genetic and sequence analysis of an 8.7-kilobase Pseudomonas denitrificans fragment carrying eight genes involved in transformation of precorrin-2 to cobyrinic acid". J. Bacteriol. 172 (10): 5980–90. 1990. doi:10.1128/JB.172.10.5980-5990.1990. PMID 2211521.
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