Biology:Polyprenol reductase

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Short description: Class of enzymes

Polyprenol reductase (EC 1.3.1.94, SRD5A3 (gene), DFG10 (gene)) is an enzyme with systematic name ditrans,polycis-dolichol:NADP+ 2,3-oxidoreductase.[1][2] This enzyme catalyses the following chemical reaction

ditrans, polycis-dolichol + NADP+ [math]\displaystyle{ \rightleftharpoons }[/math] ditrans, polycis-polyprenol + NADPH + H+

The reaction occurs in the reverse direction.

See also

References

  1. "Formation of dolichol from dehydrodolichol is catalyzed by NADPH-dependent reductase localized in microsomes of rat liver". The Journal of Biological Chemistry 268 (14): 10109–13. May 1993. PMID 8486680. 
  2. "SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder". Cell 142 (2): 203–17. July 2010. doi:10.1016/j.cell.2010.06.001. PMID 20637498. 

External links