Biology:Precorrin-3B C17-methyltransferase
| Precorrin-3B C17-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.1.131 | ||||||||
| CAS number | 152787-64-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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Precorrin-3B C17-methyltransferase (EC 2.1.1.131) is an enzyme that catalyzes the chemical reaction
- REDIRECT Template:Chemical reaction
The two substrates of this enzyme are the chlorin, precorrin-3B and S-adenosyl methionine. Its products are precorrin-4 and S-adenosylhomocysteine.[1][2][3]
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:precorrin-3B C17-methyltransferase. Other names in common use include precorrin-3 methyltransferase, and CobJ. This enzyme is part of the biosynthetic pathway to cobalamin (vitamin B12) in aerobic bacteria and during this step the macrocycle ring-contracts so that the corrin core of the vitamin is formed.
See also
References
- ↑ Enzyme 2.1.1.131 at KEGG Pathway Database.
- ↑ "Biosynthesis of vitamin B12. Discovery of the enzymes for oxidative ring contraction and insertion of the fourth methyl group". FEBS Lett. 331 (1–2): 105–8. 1993. doi:10.1016/0014-5793(93)80306-F. PMID 8405386. Bibcode: 1993FEBSL.331..105S.
- ↑ "Biosynthesis of the corrin macrocycle of coenzyme B12 in Pseudomonas denitrificans". J. Bacteriol. 175 (22): 7430–40. 1993. doi:10.1128/jb.175.22.7430-7440.1993. PMID 8226690.
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