Biology:Precorrin-6A synthase (deacetylating)
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| precorrin-6A synthase (deacetylating) | |||||||||
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| Identifiers | |||||||||
| EC number | 2.1.1.152 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, precorrin-6A synthase (deacetylating) (EC 2.1.1.152) is an enzyme that catalyzes the chemical reaction
- S-adenosyl-L-methionine + precorrin-5 + H2O [math]\displaystyle{ \rightleftharpoons }[/math] S-adenosyl-L-homocysteine + precorrin-6A + acetate
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The 3 substrates of this enzyme are S-adenosyl methionine, precorrin 5, and H2O. Its 3 products are S-adenosylhomocysteine, precorrin 6A, and acetate.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:precorrin-5 C1-methyltransferase (deacetylating). Other names in common use include precorrin-6X synthase (deacetylating), and CobF. This enzyme is part of the biosynthetic pathway to cobalamin (vitamin B12) in aerobic bacteria.
See also
References
- "Biosynthesis of the corrin macrocycle of coenzyme B12 in Pseudomonas denitrificans". J. Bacteriol. 175 (22): 7430–40. 1993. PMID 8226690.
- "The biosynthesis of adenosylcobalamin (vitamin B12)". Nat. Prod. Rep. 19 (4): 390–412. 2002. doi:10.1039/b108967f. PMID 12195810.
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