Biology:Prepilin peptidase

From HandWiki
Short description: Enzyme responsible for maturing type 4 pilins
Prepilin peptidase
Identifiers
EC number3.4.23.43
CAS number202833-59-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Type IV leader peptidase family (A24)
Identifiers
SymbolPeptidase_A24
PfamPF01478
InterProIPR000045

Prepilin peptidase (EC 3.4.23.43) is an enzyme found in Type IV filament systems responsible for the maturation of the pilin.[1][2] This enzyme catalyses the following chemical reaction

Typically cleaves a -Gly-Phe- bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine.

This enzyme is present on the surface of many species of bacteria. All known enzymes with this activity are of the MEROPS family A24.

References

  1. "Structure-function relationship of type-IV prepilin peptidase of Pseudomonas aeruginosa--a review". Gene 192 (1): 117–21. June 1997. doi:10.1016/S0378-1119(96)00830-X. PMID 9224881. 
  2. "The type 4 prepilin peptidases comprise a novel family of aspartic acid proteases". The Journal of Biological Chemistry 275 (2): 1502–10. January 2000. doi:10.1074/jbc.275.2.1502. PMID 10625704. 

External links