Biology:Progesterone 5alpha-reductase
| progesterone 5-alpha-reductase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 1.3.1.22 | ||||||||
| CAS number | 72412-84-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a progesterone 5alpha-reductase (EC 1.3.1.22) is an enzyme that catalyzes the chemical reaction
- 5alpha-pregnan-3,20-dione + NADP+ [math]\displaystyle{ \rightleftharpoons }[/math] progesterone + NADPH + H+
Thus, the two substrates of this enzyme are 5alpha-pregnan-3,20-dione and NADP+, whereas its 3 products are progesterone, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. It is a C21-steroid hormone that is a 5α-pregnane substituted with a oxo groups at positions 3 and 20. It is an intermediate in the conversion of progesterone to allopregnalone and isopregnanolone, other common forms of neurosteroids. The systematic name of this enzyme class is 5alpha-pregnan-3,20-dione:NADP+ 5-oxidoreductase. Other names in common use include steroid 5-alpha-reductase, and Delta4-steroid 5alpha-reductase (progesterone).
References
- "Subcellular distribution and properties of progesterone (delta4-steroid) 5alpha-reductase in rat medial basal hypothalamus". J. Biol. Chem. 250 (20): 7997–8003. 1975. PMID 240847.
- "Properties and subcellular distribution of delta4-steroid (progesterone) 5alpha-reductase in rat anterior pituitary". Steroids 26 (1): 57–71. 1975. doi:10.1016/0039-128X(75)90006-9. PMID 1166484.
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