Biology:Pseudomon-1 RNA motif

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Pseudomon-1 RNA
Pseudomon-1-RNA.svg
Consensus secondary structure of Pseudomon-1 RNAs
Identifiers
SymbolPseudomon-1
RfamRF01719
Other data
RNA typesRNA
Domain(s)Pseudomonas
PDB structuresPDBe

The Pseudomon-1 RNA motif is a conserved RNA identified by bioinformatics.[1] It is used by most species whose genomes have been sequenced and that are classified within the genus Pseudomonas, and is also present in Azotobacter vinelandii, a closely related species. It is presumed to function as a non-coding RNA. Pseudomon-1 RNAs consistently have a downstream rho-independent transcription terminator.

The intergenic region containing Pseudomon-1 RNAs were also detected later by an independent study based on deep sequencing and called SPA0122[2] The genes surrounding this region suggest a similarity to Spot 42 RNA,[2] but the Pseudomonas RNA functions to regulate the AlgC enzyme[3] Based on this information, the new name ErsA for the RNA was adopted.[3] Negatively regulates major porin oprD expression responsible for uptake of carbapenem antibiotics, by base pairing with oprD 5′UTR (leading to increased bacterial resistance to meropenem).[4] ErsA positively regulates amrZ mRNA and contributes to biofilm formation and motility.[5]

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