Biology:Putrescine N-methyltransferase
From HandWiki
Short description: Enzyme
| putrescine N-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.1.53 | ||||||||
| CAS number | 9075-39-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a putrescine N-methyltransferase (EC 2.1.1.53) is an enzyme that catalyzes the chemical reaction
- S-adenosyl-L-methionine + putrescine [math]\displaystyle{ \rightleftharpoons }[/math] S-adenosyl-L-homocysteine + N-methylputrescine
Thus, the two substrates of this enzyme are S-adenosyl methionine and putrescine, whereas its two products are S-adenosylhomocysteine and N-methylputrescine.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:putrescine N-methyltransferase. This enzyme is also called putrescine methyltransferase. This enzyme participates in alkaloid biosynthesis ii.
This enzyme is important in the synthesis of many plant alkaloids.[1] It evolved from spermidine synthase.[2]
References
- ↑ "Putrescine N-methyltransferase--the start for alkaloids". Phytochemistry. Evolution of Metabolic Diversity 70 (15–16): 1708–18. 2009-10-01. doi:10.1016/j.phytochem.2009.06.012. PMID 19651420.
- ↑ "Evolution of the key alkaloid enzyme putrescine N-methyltransferase from spermidine synthase". Frontiers in Plant Science 4: 260. 2013-01-01. doi:10.3389/fpls.2013.00260. PMID 23908659.
- "Phytochemical studies on tobacco alkaloids. XIV. The occurrence and properties of putrescine N-methyltransferase in tobacco roots". Plant Cell Physiol. 12: 633–640. 1971.
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