Biology:Pyrrolysine—tRNAPyl ligase
From HandWiki
| Pyrrolysine—tRNAPyl ligase | |||||||||
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| Identifiers | |||||||||
| EC number | 6.1.1.26 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Pyrrolysine—tRNAPyl ligase (EC 6.1.1.26, PylS, pyrrolysyl-tRNA synthetase) is an enzyme with systematic name L-pyrrolysine:tRNAPyl ligase (AMP-forming).[1][2][3] This enzyme catalyses the following chemical reaction
- ATP + L-pyrrolysine + tRNAPyl AMP + diphosphate + L-pyrrolysyl-tRNAPyl
This enzyme is specific for pyrrolysine as substrate as it cannot be replaced by lysine or any of the other natural amino acids.
References
- ↑ "Direct charging of tRNA(CUA) with pyrrolysine in vitro and in vivo". Nature 431 (7006): 333–5. September 2004. doi:10.1038/nature02895. PMID 15329732.
- ↑ "An aminoacyl-tRNA synthetase that specifically activates pyrrolysine". Proceedings of the National Academy of Sciences of the United States of America 101 (34): 12450–4. August 2004. doi:10.1073/pnas.0405362101. PMID 15314242.
- ↑ "Molecular biology: genetic code seizes pyrrolysine". Nature 431 (7006): 257–8. September 2004. doi:10.1038/431257a. PMID 15372017.
External links
- Pyrrolysine---tRNAPyl+ligase at the US National Library of Medicine Medical Subject Headings (MeSH)
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