Biology:rRNA (guanine-N1-)-methyltransferase

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rRNA (guanine-N1-)-methyltransferase
Identifiers
EC number2.1.1.51
CAS number50812-25-4
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a rRNA (guanine-N1-)-methyltransferase (EC 2.1.1.51) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + rRNA [math]\displaystyle{ \rightleftharpoons }[/math] S-adenosyl-L-homocysteine + rRNA containing N1-methylguanine

Thus, the two substrates of this enzyme are S-adenosyl methionine and rRNA, whereas its two products are S-adenosylhomocysteine and rRNA containing N1-methylguanine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:rRNA (guanine-N1-)-methyltransferase. Other names in common use include ribosomal ribonucleate guanine 1-methyltransferase, and S-adenosyl-L-methionine:rRNA (guanine-1-N-)-methyltransferase.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1P91.

References

  • "Partial purification of ribosomal RNA(m1G)- and rRNA(m2G)-methylases from Escherichia coli and demonstration of some proteins affecting their apparent activity". Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis 312 (1): 122–33. June 1973. doi:10.1016/0005-2787(73)90057-9. PMID 4580201.