Biology:Rubredoxin—NAD(P)(+) reductase

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Short description: Enzyme
rubredoxin—NAD(P)+ reductase
Identifiers
EC number1.18.1.4
CAS number114514-31-7
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a rubredoxin—NAD(P)+ reductase (EC 1.18.1.4) is an enzyme that catalyzes the chemical reaction

reduced rubredoxin + NAD(P)+ [math]\displaystyle{ \rightleftharpoons }[/math] oxidized rubredoxin + NAD(P)H + H+

The 3 substrates of this enzyme are reduced rubredoxin, NAD+, and NADP+, whereas its 4 products are oxidized rubredoxin, NADH, NADPH, and H+.[1][2]

This enzyme belongs to the family of oxidoreductases, specifically those acting on iron-sulfur proteins as donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is rubredoxin:NAD(P)+ oxidoreductase. Other names in common use include rubredoxin-nicotinamide adenine dinucleotide (phosphate) reductase, rubredoxin-nicotinamide adenine, dinucleotide phosphate reductase, NAD(P)+-rubredoxin oxidoreductase, and NAD(P)H-rubredoxin oxidoreductase. This enzyme participates in fatty acid metabolism.

References

  1. "Detection of NAD(P)H--rubredoxin oxidoreductases in Clostridia". Analytical Biochemistry 116 (2): 564–70. September 1981. doi:10.1016/0003-2697(81)90403-6. PMID 6274224. 
  2. "A hyperactive NAD(P)H:Rubredoxin oxidoreductase from the hyperthermophilic archaeon Pyrococcus furiosus". Journal of Bacteriology 181 (17): 5530–3. September 1999. PMID 10464233. 

External links