Biology:SMG1
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Serine/threonine-protein kinase SMG1 is an enzyme that in humans is encoded by the SMG1 gene.[1][2][3][4] SMG1 belongs to the phosphatidylinositol 3-kinase-related kinase protein family.
Function
This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternative spliced transcript variants have been described, but their full-length natures have not been determined.[4]
Interactions
SMG1 (gene) has been shown to interact with PRKCI[5] and UPF1.[6]
References
- ↑ "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. 1998. doi:10.1093/dnares/4.5.307. PMID 9455477.
- ↑ "Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein". J. Biol. Chem. 276 (25): 22709–14. June 2001. doi:10.1074/jbc.C100144200. PMID 11331269.
- ↑ "Distant N- and C-terminal domains are required for intrinsic kinase activity of SMG-1, a critical component of nonsense-mediated mRNA decay". J. Biol. Chem. 282 (11): 7799–808. March 2007. doi:10.1074/jbc.M610159200. PMID 17229728.
- ↑ 4.0 4.1 "Entrez Gene: SMG1 PI-3-kinase-related kinase SMG-1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23049.
- ↑ "Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo". Mol. Cell. Biol. 16 (1): 105–14. January 1996. doi:10.1128/mcb.16.1.105. PMID 8524286.
- ↑ "Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay". Genes Dev. 15 (17): 2215–28. September 2001. doi:10.1101/gad.913001. PMID 11544179.
Further reading
- "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. 2002. doi:10.1093/dnares/9.3.99. PMID 12168954.
- "The ATM-related kinase, hSMG-1, bridges genome and RNA surveillance pathways". DNA Repair (Amst.) 3 (8–9): 919–25. 2005. doi:10.1016/j.dnarep.2004.04.003. PMID 15279777.
- "Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo". Mol. Cell. Biol. 16 (1): 105–14. 1996. doi:10.1128/MCB.16.1.105. PMID 8524286.
- "Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62". Mol. Cell. Biol. 18 (5): 3069–80. 1998. doi:10.1128/mcb.18.5.3069. PMID 9566925.
- "Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis". Cell 98 (2): 147–57. 1999. doi:10.1016/S0092-8674(00)81010-7. PMID 10428027.
- "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics 60 (3): 295–308. 1999. doi:10.1006/geno.1999.5927. PMID 10493829.
- "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. 2000. doi:10.1073/pnas.97.7.3491. PMID 10737800. Bibcode: 2000PNAS...97.3491D.
- "Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay". Genes Dev. 15 (17): 2215–28. 2001. doi:10.1101/gad.913001. PMID 11544179.
- "Divergent origins and concerted expansion of two segmental duplications on chromosome 16". J. Hered. 92 (6): 462–8. 2002. doi:10.1093/jhered/92.6.462. PMID 11948212.
- "Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1". RNA 9 (1): 77–87. 2003. doi:10.1261/rna.2137903. PMID 12554878.
- "Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7". Mol. Cell 12 (5): 1187–200. 2003. doi:10.1016/S1097-2765(03)00443-X. PMID 14636577.
- "The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells". Mol. Cell 14 (5): 585–98. 2004. doi:10.1016/j.molcel.2004.05.005. PMID 15175154.
- "Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay". Genes Dev. 20 (3): 355–67. 2006. doi:10.1101/gad.1389006. PMID 16452507.
- "The human RNA surveillance factor UPF1 is required for S phase progression and genome stability". Curr. Biol. 16 (4): 433–9. 2006. doi:10.1016/j.cub.2006.01.018. PMID 16488880.
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