Biology:SNX1
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Sorting nexin-1 is a protein that in humans is encoded by the SNX1 gene. The protein encoded by this gene is a sorting nexin.[1] SNX1 is a component of the retromer complex.[2][3]
Function
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with other family members.[4]
References
- ↑ "Enhanced degradation of EGF receptors by a sorting nexin, SNX1". Science 272 (5264): 1008–10. May 1996. doi:10.1126/science.272.5264.1008. PMID 8638121. Bibcode: 1996Sci...272.1008K.
- ↑ Vergés M (2008). "Retromer: multipurpose sorting and specialization in polarized transport". Int Rev Cell Mol Biol. International Review of Cell and Molecular Biology 271: 153–98. doi:10.1016/S1937-6448(08)01204-5. ISBN 9780123747280. PMID 19081543.
- ↑ "Retromer". Curr. Opin. Cell Biol. 20 (4): 427–36. August 2008. doi:10.1016/j.ceb.2008.03.009. PMID 18472259.
- ↑ "Entrez Gene: sorting nexin 1". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=6642.
Further reading
- "Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases.". J. Biol. Chem. 276 (22): 19332–9. 2001. doi:10.1074/jbc.M100606200. PMID 11279102.
- "The phox homology (PX) domain-dependent, 3-phosphoinositide-mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradation.". J. Biol. Chem. 277 (50): 48730–6. 2002. doi:10.1074/jbc.M206986200. PMID 12198132.
- "Structural and functional characterization of the human gene for sorting nexin 1 (SNX1).". DNA Cell Biol. 20 (5): 287–96. 2001. doi:10.1089/104454901750232481. PMID 11410165.
- "Inhibitory regulation of EGF receptor degradation by sorting nexin 5.". Biochem. Biophys. Res. Commun. 342 (2): 537–46. 2006. doi:10.1016/j.bbrc.2006.01.179. PMID 16487940. Bibcode: 2006BBRC..342..537L.
- "EGF induces macropinocytosis and SNX1-modulated recycling of E-cadherin.". J. Cell Sci. 120 (Pt 10): 1818–28. 2007. doi:10.1242/jcs.000653. PMID 17502486.
- "A novel hook-related protein family and the characterization of hook-related protein 1.". Traffic 6 (6): 442–58. 2005. doi:10.1111/j.1600-0854.2005.00289.x. PMID 15882442.
- "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis.". Exp. Cell Res. 288 (1): 35–50. 2003. doi:10.1016/S0014-4827(03)00130-7. PMID 12878157.
- "Determinants of the endosomal localization of sorting nexin 1.". Mol. Biol. Cell 16 (4): 2049–57. 2005. doi:10.1091/mbc.E04-06-0504. PMID 15673616.
- "SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors.". Traffic 9 (3): 380–93. 2008. doi:10.1111/j.1600-0854.2007.00686.x. PMID 18088323.
- "Sorting nexin 1 down-regulation promotes colon tumorigenesis.". Clin. Cancer Res. 12 (23): 6952–9. 2006. doi:10.1158/1078-0432.CCR-06-0317. PMID 17145813.
- "Enterophilin-1, a new partner of sorting nexin 1, decreases cell surface epidermal growth factor receptor.". J. Biol. Chem. 278 (23): 21155–61. 2003. doi:10.1074/jbc.M211008200. PMID 12657642.
- "Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors.". Mol. Cell. Biol. 27 (3): 1112–24. 2007. doi:10.1128/MCB.00156-06. PMID 17101778.
- "An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexins.". Mol. Biol. Cell 17 (3): 1228–38. 2006. doi:10.1091/mbc.E05-09-0899. PMID 16407403.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Endosomal localization and function of sorting nexin 1.". Proc. Natl. Acad. Sci. U.S.A. 99 (10): 6767–72. 2002. doi:10.1073/pnas.092142699. PMID 11997453. Bibcode: 2002PNAS...99.6767Z.
- "Down-regulation of protease-activated receptor-1 is regulated by sorting nexin 1.". Mol. Biol. Cell 13 (6): 1965–76. 2002. doi:10.1091/mbc.E01-11-0131. PMID 12058063.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2002. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides.". Curr. Biol. 14 (20): 1791–800. 2004. doi:10.1016/j.cub.2004.09.077. PMID 15498486. Bibcode: 2004CBio...14.1791C.
- "Self-assembly and binding of a sorting nexin to sorting endosomes.". J. Cell Sci. 114 (Pt 9): 1743–56. 2001. doi:10.1242/jcs.114.9.1743. PMID 11309204.
External links
- sorting+nexins at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 |  |
