Biology:Small Cajal body specific RNA 13
From HandWiki
| Small Cajal body specific RNA 13 | |
|---|---|
 Predicted secondary structure and sequence conservation of SCARNA13 | |
| Identifiers | |
| Symbol | SCARNA13 |
| Alt. Symbols | U93 |
| Rfam | RF00231 |
| Other data | |
| RNA type | Gene; snRNA; snoRNA; scaRNA |
| Domain(s) | Eukaryota |
| GO | 0006396 0015030 0005730 |
| SO | 0000275 |
| PDB structures | PDBe |
In molecular biology, Small Cajal body specific RNA 13 (also known as scaRNA13 or U93) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation of U2 and U5 spliceosomal RNA.
scaRNAs are a specific class of small nucleolar RNAs that localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.[1]
U93 is composed of two tandemly arranged box H/ACA box sequence motifs and belongs to the H/ACA box class of guide RNAs.[2] U93 is predicted to guide pseudouridylation of U2 spliceosomal snRNA residue U54 and residue U53 of snRNA U5.[2][3][4]
References
- ↑ Darzacq, Xavier; Jády, Beáta E.; Verheggen, Céline; Kiss, Arnold M.; Bertrand, Edouard; Kiss, Tamás (2002). "Cajal body-specific small nuclear RNAs: A novel class of 2'-O-methylation and pseudouridylation guide RNAs". The EMBO Journal 21 (11): 2746–2756. doi:10.1093/emboj/21.11.2746. PMID 12032087.
- ↑ 2.0 2.1 "A Cajal body-specific pseudouridylation guide RNA is composed of two box H/ACA snoRNA-like domains". Nucleic Acids Res. 30 (21): 4643–9. 2002. doi:10.1093/nar/gkf592. PMID 12409454.
- ↑ Lestrade, Laurent; Weber, Michel J. (2006). "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research 34 (Supplement 1: Database Issue): D158–D162. doi:10.1093/nar/gkj002. PMID 16381836.
- ↑ "A computational screen for mammalian pseudouridylation guide H/ACA RNAs". RNA 12 (1): 15–25. 2006. doi:10.1261/rna.2210406. PMID 16373490.
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