Biology:Small Cajal body specific RNA 24
From HandWiki
| Small Cajal body specific RNA 24 | |
|---|---|
 Predicted secondary structure and sequence conservation of SCARNA24 | |
| Identifiers | |
| Symbol | SCARNA24 |
| Alt. Symbols | snoACA12 |
| Rfam | RF00422 |
| Other data | |
| RNA type | Gene; snRNA; snoRNA; scaRNA |
| Domain(s) | Eukaryota |
| GO | 0006396 0015030 0005730 |
| SO | 0000275 |
| PDB structures | PDBe |
Small Cajal body specific RNA 24 (also known as scaRNA24 or ACA12) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation (isomerisation of uridine to pseudouridine) of U6 spliceosomal RNA.
scaRNAs are a specific class of small nucleolar RNAs that localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.[1]
ACA12 belongs to the H/ACA box class of guide RNAs as it has the predicted hairpin-hinge-hairpin-tail structure, the conserved H/ACA-box motifs and is found associated with GAR1 protein.[2] ACA12 is predicted to guide the pseudouridylation of residue U40 of the spliceosomal U6 snRNA.[2][3]
References
- ↑ "Cajal body-specific small nuclear RNAs: a novel class of 2'-O-methylation and pseudouridylation guide RNAs". The EMBO Journal 21 (11): 2746–56. June 2002. doi:10.1093/emboj/21.11.2746. PMID 12032087.
- ↑ 2.0 2.1 "Human box H/ACA pseudouridylation guide RNA machinery". Molecular and Cellular Biology 24 (13): 5797–807. July 2004. doi:10.1128/MCB.24.13.5797-5807.2004. PMID 15199136.
- ↑ "snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs". Nucleic Acids Research 34 (Database issue): D158-62. January 2006. doi:10.1093/nar/gkj002. PMID 16381836.
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