Biology:Sulfinoalanine decarboxylase
| Sulfinoalanine decarboxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Cysteine sulfinic acid decarboxylase homodimer, Human | |||||||||
| Identifiers | |||||||||
| EC number | 4.1.1.29 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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The enzyme sulfinoalanine decarboxylase (EC 4.1.1.29) catalyzes the chemical reaction
- 3-sulfino-L-alanine [math]\displaystyle{ \rightleftharpoons }[/math] hypotaurine + CO2
Hence, this enzyme has one substrate, 3-sulfino-L-alanine (also known as Cysteine sulfinic acid), and two products, hypotaurine and CO2.
This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 3-sulfino-L-alanine carboxy-lyase (hypotaurine-forming). Other names in common use include cysteine-sulfinate decarboxylase, L-cysteinesulfinic acid decarboxylase, cysteine-sulfinate decarboxylase, CADCase/CSADCase, CSAD, cysteic decarboxylase, cysteinesulfinic acid decarboxylase, cysteinesulfinate decarboxylase, sulfoalanine decarboxylase, and 3-sulfino-L-alanine carboxy-lyase. This enzyme participates in taurine metabolism. It employs one cofactor, pyridoxal phosphate.
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2JIS.
References
- "Rat liver cysteine sulfinate decarboxylase: purification, new appraisal of the molecular weight and determination of catalytic properties". Biochim. Biophys. Acta 384 (1): 265–76. 1975. doi:10.1016/0005-2744(75)90115-1. PMID 236774.
- "Properties and Distribution of Mammalian L-Cysteine Sulfinate Carboxy-Lyases". Biochim. Biophys. Acta 85: 103–16. 1964. doi:10.1016/0926-6569(64)90171-3. PMID 14159288.
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