Biology:tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase
tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase | |||||||||
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Identifiers | |||||||||
EC number | 2.1.1.61 | ||||||||
CAS number | 39391-17-8 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase (EC 2.1.1.61) is an enzyme that catalyzes the chemical reaction
- S-adenosyl-L-methionine + tRNA [math]\displaystyle{ \rightleftharpoons }[/math] S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate
Thus, the two substrates of this enzyme are S-adenosyl methionine and tRNA, whereas its two products are S-adenosylhomocysteine and tRNA containing 5-methylaminomethyl-2-thiouridylic acid.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:tRNA (5-methylaminomethyl-2-thio-uridylate)-methyltransferase. Other names in common use include transfer ribonucleate 5-methylaminomethyl-2-thiouridylate, 5-methyltransferase, and tRNA 5-methylaminomethyl-2-thiouridylate 5'-methyltransferase.
Structural studies
As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 2DER, 2DET, 2DEU, and 2HMA.
References
- "Biosynthesis of 5-methylaminomethyl-2-thiouridylate. I. Isolation of a new tRNA-methylase specific for 5-methylaminomethyl-2-thiouridylate". Biochem. Biophys. Res. Commun. 51 (4): 1062–8. 1973. doi:10.1016/0006-291X(73)90035-1. PMID 4703553.
- Salvatore, F., ed (1977). The Biochemistry of Adenosylmethionine. New York: Columbia University Press. p. 251.
![]() | Original source: https://en.wikipedia.org/wiki/TRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase.
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