Biology:tRNA (adenine-N1-)-methyltransferase
| tRNA (adenine-N1-)-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.1.36 | ||||||||
| CAS number | 37257-03-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a tRNA (adenine-N1-)-methyltransferase (EC 2.1.1.36) is an enzyme that catalyzes the chemical reaction
- S-adenosyl-L-methionine + tRNA [math]\displaystyle{ \rightleftharpoons }[/math] S-adenosyl-L-homocysteine + tRNA containing N1-methyladenine
Thus, the two substrates of this enzyme are S-adenosyl methionine and tRNA, whereas its two products are S-adenosylhomocysteine and tRNA containing N1-methyladenine.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:tRNA (adenine-N1-)-methyltransferase. Other names in common use include transfer ribonucleate adenine 1-methyltransferase, transfer RNA (adenine-1) methyltransferase, 1-methyladenine transfer RNA methyltransferase, adenine-1-methylase, and S-adenosyl-L-methionine:tRNA (adenine-1-N-)-methyltransferase.
References
- "The specificity of transfer ribonucleic acid methylases from rat liver". Biochemistry 7 (1): 45–50. 1968. doi:10.1021/bi00841a007. PMID 4921283.
- "Studies on microbial RNA. Fractionation of tRNA methylases from Saccharomyces cerevisiae". Eur. J. Biochem. 9 (2): 207–15. 1969. doi:10.1111/j.1432-1033.1969.tb00596.x. PMID 4896260.
- "Methylation of yeast tRNA Asp by enzymes from cytoplasm, chloroplasts and mitochondria of phaseolus vulgaris". Biochim. Biophys. Acta 374 (3): 332–41. 1974. doi:10.1016/0005-2787(74)90254-8. PMID 4611497.
- "Purification and properties of tRNA(adenine-1)-methyltransferase from rat liver". J. Biol. Chem. 252 (14): 4790–5. 1977. PMID 17605.
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