Biology:TRNA dimethylallyltransferase
From HandWiki
| TRNA dimethylallyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.5.1.75 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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TRNA dimethylallyltransferase (EC 2.5.1.75, tRNA prenyltransferase, MiaA, transfer ribonucleate isopentenyltransferase, Delta2-isopentenyl pyrophosphate:tRNA-Delta2-isopentenyl transferase, Delta2-isopentenyl pyrophosphate:transfer ribonucleic acid Delta2-isopentenyltransferase) is an enzyme with systematic name dimethylallyl-diphosphate: tRNA dimethylallyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction
- dimethylallyl diphosphate + tRNA [math]\displaystyle{ \rightleftharpoons }[/math] diphosphate + tRNA containing 6-dimethylallyladenosine
Formerly known as tRNA isopentenyltransferase (EC 2.5.1.8), but it is now known that dimethylallyl diphosphate, rather than isopentenyl diphosphate, is the substrate.
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2QGN.
References
- ↑ "Regulation of substrate recognition by the MiaA tRNA prenyltransferase modification enzyme of Escherichia coli K-12". The Journal of Biological Chemistry 272 (20): 13073–83. May 1997. doi:10.1074/jbc.272.20.13073. PMID 9148919.
- ↑ "Escherichia coli dimethylallyl diphosphate:tRNA dimethylallyltransferase: essential elements for recognition of tRNA substrates within the anticodon stem-loop". Biochemistry 39 (21): 6546–53. May 2000. doi:10.1021/bi992775u. PMID 10828971.
- ↑ "Escherichia coli dimethylallyl diphosphate:tRNA dimethylallyltransferase: pre-steady-state kinetic studies". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology 1479 (1–2): 166–74. June 2000. doi:10.1016/S0167-4838(00)00031-5. PMID 11004538.
Literature
- "N6-(Δ2-isopentenyl)adenosine. Biosynthesis in transfer ribonucleic acid in vitro". Biochemistry 8 (11): 4361–4371. 1969. doi:10.1021/bi00839a021. PMID 4311031.
- "Δ2-Isopentenylpyrophosphate: Transfer Ribonucleic Acid Δ2-Isopentenyltransferase from Escherichia coli. Purification and properties of the enzyme". J. Biol. Chem. 247 (18): 5675–5680. 1972. PMID 4341485.
External links
- TRNA+dimethylallyltransferase at the US National Library of Medicine Medical Subject Headings (MeSH)
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