Biology:Tabersonine 16-O-methyltransferase
11-O-demethyl-17-O-deacetylvindoline O-methyltransferase | |||||||||
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Identifiers | |||||||||
EC number | 2.1.1.94 | ||||||||
CAS number | 100984-95-0 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a tabersonine 16-O-methyltransferase (EC 2.1.1.94) is an enzyme that catalyzes the chemical reaction
- S-adenosyl-L-methionine + 16-hydroxytabersonine [math]\displaystyle{ \rightleftharpoons }[/math] S-adenosyl-L-homocysteine + 16-methoxytabersonine
Thus, the two substrates of this enzyme are S-adenosyl methionine and 16-hydroxytabersonine, whereas its two products are S-adenosylhomocysteine and 16-methoxytabersonine.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:16-hydroxytabersonine 16-O-methyltransferase. Other names in common use include 11-demethyl-17-deacetylvindoline 11-methyltransferase, 11-O-demethyl-17-O-deacetylvindoline O-methyltransferase, S-adenosyl-L-methionine:11-O-demethyl-17-O-deacetylvindoline, and 11-O-methyltransferase. This enzyme participates in terpene indole and ipecac alkaloid biosynthesis.
References
- "A proteomic analysis of arsenical drug resistance in Trypanosoma brucei". Proteomics 6 (9): 2726–32. 2006. doi:10.1002/pmic.200500419. PMID 16526094.
- "Late enzymes of vindoline biosynthesis S-Adenosyl-L-methionine:11-O-demethyl-17-O-deacetylvindoline 11-O-methylase and unspecific acetylesterase". Plant Cell Rep. 4: 337–340. 1985. doi:10.1007/bf00269893.
![]() | Original source: https://en.wikipedia.org/wiki/Tabersonine 16-O-methyltransferase.
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