Biology:Tabersonine 16-O-methyltransferase
| Tabersonine 16-O-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.1.94 | ||||||||
| CAS number | 100984-95-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Tabersonine 16-O-methyltransferase (EC 2.1.1.94) is an enzyme that catalyzes the chemical reaction
- REDIRECT Template:Chemical reaction
This is a methylation reaction in which the indole alkaloid, 16-hydroxytabersonine, is converted to 16-methoxytabersonine in Catharanthus roseus. The methyl group comes from the cofactor, S-adenosyl methionine (SAM), which becomes S-adenosyl-L-homocysteine (SAH).[1][2]
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:16-hydroxytabersonine 16-O-methyltransferase. Other names in common use include 11-demethyl-17-deacetylvindoline 11-methyltransferase, 11-O-demethyl-17-O-deacetylvindoline O-methyltransferase, S-adenosyl-L-methionine:11-O-demethyl-17-O-deacetylvindoline, and 11-O-methyltransferase. This enzyme participates in terpene indole and ipecac alkaloid biosynthesis.[3]
References
- ↑ "Late enzymes of vindoline biosynthesis : S-Adenosyl-L-methionine: 11-O-demethyl-17-O-deacetylvindoline 11-O-methyltransferase and unspecific acetylesterase". Plant Cell Reports 4 (6): 337–340. December 1985. doi:10.1007/bf00269893. PMID 24254077.
- ↑ "Biosynthesis of Indole Alkaloids: Developmental Regulation of the Biosynthetic Pathway from Tabersonine to Vindoline in Catharanthus roseus". Journal of Plant Physiology 125 (1–2): 147–156. 1986. doi:10.1016/S0176-1617(86)80252-8.
- ↑ Enzyme 2.1.1.94 at KEGG Pathway Database.
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