Biology:Tetrahydrocolumbamine 2-O-methyltransferase
| tetrahydrocolumbamine 2-O-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 2.1.1.89 | ||||||||
| CAS number | 93792-09-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, tetrahydrocolumbamine 2-O-methyltransferase (EC 2.1.1.89) is an enzyme that catalyzes the chemical reaction:[1][2]
- REDIRECT Template:Chemical reaction
In this methylation reaction, the enzyme uses the cofactor, S-adenosyl methionine (SAM) which transfers a methyl group, giving S-adenosyl-L-homocysteine (SAH) as a by-product. There are several similar transformations in the chemistry of isoquinoline alkaloids.[3][4]
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:5,8,13,13a-tetrahydrocolumbamine 2-O-methyltransferase. This enzyme is also called tetrahydrocolumbamine methyltransferase. This enzyme participates in alkaloid biosynthesis.
References
- ↑ Enzyme 2.1.1.8 at KEGG Pathway Database.
- ↑ "Enzymatic study of the late stages of protoberberine alkaloid biosynthesis". Tetrahedron Lett. 25 (41): 4595–4598. 1984. doi:10.1016/S0040-4039(01)91208-0.
- ↑ Tian, Ya; Kong, Lingzhe; Li, Qi; Wang, Yifan; Wang, Yongmiao; An, Zhoujie; Ma, Yuwei; Tian, Lixia et al. (2024). "Structural diversity, evolutionary origin, and metabolic engineering of plant specialized benzylisoquinoline alkaloids". Natural Product Reports 41 (11): 1787–1810. doi:10.1039/d4np00029c. PMID 39360417.
- ↑ "Partial purification and characterization of S-adenosyl-L-methionine:(S)-tetrahydroprotoberberine cis-N-methyltransferase from suspension-cultured cells of Eschscholtzia and Corydalis". Phytochemistry 29 (12): 3727–3733. 1990. doi:10.1016/0031-9422(90)85321-6. https://epub.ub.uni-muenchen.de/3618/1/003.pdf.
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