Biology:Thiazole tautomerase
From HandWiki
| Thiazole tautomerase | |||||||||
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| Identifiers | |||||||||
| EC number | 5.3.99.10 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Thiazole tautomerase (EC 5.3.99.10, tenI (gene)) is an enzyme with systematic name 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate isomerase.[1] This enzyme catalyses the following chemical reaction
- 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate [math]\displaystyle{ \rightleftharpoons }[/math] 2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate
The enzyme catalyses the irreversible aromatization of the thiazole moiety of 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate.
References
- ↑ "A missing enzyme in thiamin thiazole biosynthesis: identification of TenI as a thiazole tautomerase". Journal of the American Chemical Society 133 (24): 9311–9. June 2011. doi:10.1021/ja1110514. PMID 21534620.
External links
- Thiazole+tautomerase at the US National Library of Medicine Medical Subject Headings (MeSH)
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