Biology:Trans-2,3-dihydro-3-hydroxyanthranilate isomerase

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Trans-2,3-dihydro-3-hydroxyanthranilate isomerase
Identifiers
EC number5.3.3.17
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Trans-2,3-dihydro-3-hydroxyanthranilate isomerase (EC 5.3.3.17, phzF (gene)) is an enzyme with systematic name (5S,6S)-6-amino-5-hydroxycyclohexane-1,3-diene-1-carboxyate isomerase.[1][2][3][4][5] This enzyme catalyses the following chemical reaction

(5S,6S)-6-amino-5-hydroxycyclohexane-1,3-diene-1-carboxyate [math]\displaystyle{ \rightleftharpoons }[/math] (1R,6S)-6-amino-5-oxocyclohex-2-ene-1-carboxylate

The enzyme is involved in phenazine biosynthesis.

References

  1. "Structure and function of the phenazine biosynthesis protein PhzF from Pseudomonas fluorescens 2-79". Biochemistry 43 (39): 12427–35. October 2004. doi:10.1021/bi049059z. PMID 15449932. 
  2. "Structure and function of the phenazine biosynthetic protein PhzF from Pseudomonas fluorescens". Proceedings of the National Academy of Sciences of the United States of America 101 (47): 16431–6. November 2004. doi:10.1073/pnas.0407371101. PMID 15545603. 
  3. "Structure of the phenazine biosynthesis enzyme PhzG". Acta Crystallographica Section D 60 (Pt 11): 2110–3. November 2004. doi:10.1107/s0907444904022474. PMID 15502343. http://journals.iucr.org/d/issues/2004/11/00/hm5022/hm5022.pdf. 
  4. "The purification, crystallization and preliminary structural characterization of PhzF, a key enzyme in the phenazine-biosynthesis pathway from Pseudomonas fluorescens 2-79". Acta Crystallographica Section D 60 (Pt 1): 184–6. January 2004. doi:10.1107/s090744490302571x. PMID 14684924. 
  5. "PhzA/B catalyzes the formation of the tricycle in phenazine biosynthesis". Journal of the American Chemical Society 130 (50): 17053–61. December 2008. doi:10.1021/ja806325k. PMID 19053436. 

External links