Biology:Trypsin-2

Trypsin-2 (also called serine protease 2) is an enzyme that in humans is encoded by the PRSS2 gene. Trypsin-2 is a digestive enzyme which functions to break down proteins as a protease. Like other trypsins it is secreted in its inactive, trypsinogen form by the acinar cells of the pancreas into the small intestines as part of pancreatic juice. It is distinctive in its potential ability to degrade type II collagen, which may be connected to rheumatoid arthritis.

Function

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008].

Further reading

• "Human trypsinogen in colorectal cancer". International Journal of Cancer 93 (1): 67–73. July 2001. doi:10.1002/ijc.1304. PMID 11391623. 
• "Validity of the urinary trypsinogen-2 test in the diagnosis of acute pancreatitis". Pancreas 41 (6): 869–875. August 2012. doi:10.1097/MPA.0b013e3182480ab7. PMID 22481290. 
• "PRSS1-Related Hereditary Pancreatitis". GeneReviews^®. Seattle (WA): University of Washington, Seattle. 2025. https://www.ncbi.nlm.nih.gov/books/NBK84399/. 
• "Protein profiling of human pancreatic islets by two-dimensional gel electrophoresis and mass spectrometry". Journal of Proteome Research 4 (3): 931–940. 2005. doi:10.1021/pr050024a. PMID 15952740. 
• "Trypsin-2 enhances carcinoma invasion by processing tight junctions and activating ProMT1-MMP". Cancer Investigation 30 (8): 583–592. October 2012. doi:10.3109/07357907.2012.716467. PMID 22909050. 
• "Enhanced detection of cholangiocarcinoma with serum trypsinogen-2 in patients with severe bile duct strictures". Journal of Hepatology 47 (5): 677–683. November 2007. doi:10.1016/j.jhep.2007.05.017. PMID 17640760. 
• "Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes". Journal of Neurovirology 9 (3): 358–371. June 2003. doi:10.1080/13550280390201119. PMID 12775419. 
• "The origin of trypsin: evidence for multiple gene duplications in trypsins". Journal of Molecular Evolution 47 (3): 353–362. September 1998. doi:10.1007/PL00006393. PMID 9732462. Bibcode: 1998JMolE..47..353B. 
• "Identification of pancreatic juice proteins as biomarkers of pancreatic cancer". Oncology Reports 23 (6): 1683–1692. June 2010. doi:10.3892/or_00000812. PMID 20428826. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.