Biology:Tubulin—tyrosine ligase

From HandWiki
Short description: Class of enzymes
Tubulin—tyrosine ligase
Identifiers
EC number6.3.2.25
CAS number60321-03-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO

In enzymology, a tubulin—tyrosine ligase (EC 6.3.2.25) is an enzyme that catalyzes the chemical reaction

ATP + detyrosinated α-tubulin + L-tyrosine [math]\displaystyle{ \rightleftharpoons }[/math] α-tubulin + ADP + phosphate

The 3 substrates of this enzyme are ATP, detyrosinated alpha-tubulin, and L-tyrosine, whereas its 3 products are alpha-tubulin, ADP, and phosphate.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is alpha-tubulin:L-tyrosine ligase (ADP-forming).

References